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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neuroimaging
2016 ; 26
(2
): 219-23
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English Wikipedia
FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis
in Patients With Acute Stroke Due to Proximal Artery Occlusion
#MMPMID26250448
Karadeli HH
; Giurgiutiu DV
; Cloonan L
; Fitzpatrick K
; Kanakis A
; Ozcan ME
; Schwamm LH
; Rost NS
J Neuroimaging
2016[Mar]; 26
(2
): 219-23
PMID26250448
show ga
BACKGROUND: Fluid attenuated inversion recovery (FLAIR) vascular hyperintensity
(FVH) is a novel radiographic marker detected in acute ischemic stroke (AIS)
patients, which is linked to slow blood flow and potentially salvageable brain
tissue. Poor leptomeningeal collateral status in AIS patients with proximal
artery occlusion (PAO) is associated with larger final infarct and worse clinical
outcomes, which are also affected by severity of white matter hyperintensity
(WMH). We sought to evaluate FVH utility as a marker of acute collateral vessel
status and its association with WMH burden in AIS patients. METHODS: Consecutive
AIS patients with PAO on baseline CT angiography (CTA) were retrospectively
selected from a prospectively derived database. FVH was graded by its location,
degree, and score on admission MRI obtained immediately after intravenous tissue
plasminogen activator administration. Leptomeningeal collateral flow grade was
ranked on admission CTA. WMH volume (WMHV) was assessed using a validated
volumetric protocol. Relationship between FVH, collateral flow grade, and WMHV
were analyzed. RESULTS: Among 39 patients (mean age 70.5 ± 12.7 years; 56% women,
mean National Institutes of Health Stroke Scale score 17.2 (± 4.4)), median WMHV
was 6.0 cm(3). FVH score and collateral flow grade were significantly correlated
(Spearman's ? = .41, P = .009). In a univariate regression model, FVH degree was
inversely associated with WMHV (? = -.33, P = .04). CONCLUSIONS: FVH score
detected on acute MRI can be used as a surrogate of collateral flow grade in AIS
patients. FVH degree is inversely associated with WMHV, possibly signifying
diffuse disease of cerebral vasculature in patients with severe leukoaraiosis.