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10.1016/j.surg.2015.10.022 http://scihub22266oqcxt.onion/10.1016/j.surg.2015.10.022 C4744557!4744557!26619928     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Surgery 2016 ; 159 (3): 852-61 Nephropedia Template TP {{tp|p=26619928|t=2016. Donor Gluconate Rescues Livers from Uncontrolled Donation after Cardiac Death |pdf=|usr=}}{{26619928}} gab.com Text Donor Gluconate Rescues Livers from Uncontrolled Donation after Cardiac Death JO: Surgery http://www.kidney.de/pget.php?&tw=1&pmid=26619928 #FOAvip Background: Ischemia from organ preservation or donation causes cells and tissues to swell due to loss of energy-dependent mechanisms of control of cell volume. These volume changes cause substantial preservation injury, because preventing these changes by adding cell impermeants to preservation solutions decreases preservation injury. The objective of this study was to assess if this effect could be realized early in uncontrolled donation after cardiac death (DCD) livers by systemically loading donors with gluconate immediately after death to prevent accelerated swelling injury during the warm ischemia period prior to liver retrieval. Methods: Uncontrolled DCD rat livers were cold-stored in UW solution for 24 hours and reperfused on an isolated perfused liver (IPL) device for two hours or transplanted into a rat as an allograft for 7 days. Donors were pre-treated with a solution of the impermeant gluconate or a saline control immediately after cardiac death. Livers were retrieved after 30 minutes. Results: In-vivo, gluconate-infused in donors immediately before or after cardiac death prevented DCD induced increases in total tissue water (TTW), decreased vascular resistance, increased oxygen consumption and ATP synthesis, increased bile production, decreased LDH release, and decreased histology injury scores after reperfusion on the IPL relative to saline-treated DCD controls. In the transplant model, donor gluconate pretreatment significantly decreased both ALT the first day after transplantation and total bilirubin the seventh day after transplantation. Conclusions: Cell and tissue swelling plays a key role in preservation injury of uncontrolled DCD livers, which can be mitigated by early administration of gluconate solutions to the donor immediately after death. Twit Text FOAVip Donor Gluconate Rescues Livers from Uncontrolled Donation after Cardiac Death ????Surgery http://www.kidney.de/pget.php?&tw=1&pmid=26619928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26619928 #FOAvip English Wikipedia <ref>{{Cite pmid|26619928}}</ref> Donor Gluconate Rescues Livers from Uncontrolled Donation after Cardiac Death #MMPMID26619928 Limkemann A; Lindell SL; Reichstetter H; Plant V; Parrish D; Ramos C; Kowalski C; Quintini C; Mangino MJ Surgery 2016[Mar]; 159 (3): 852-61 PMID26619928show ga Background: Ischemia from organ preservation or donation causes cells and tissues to swell due to loss of energy-dependent mechanisms of control of cell volume. These volume changes cause substantial preservation injury, because preventing these changes by adding cell impermeants to preservation solutions decreases preservation injury. The objective of this study was to assess if this effect could be realized early in uncontrolled donation after cardiac death (DCD) livers by systemically loading donors with gluconate immediately after death to prevent accelerated swelling injury during the warm ischemia period prior to liver retrieval. Methods: Uncontrolled DCD rat livers were cold-stored in UW solution for 24 hours and reperfused on an isolated perfused liver (IPL) device for two hours or transplanted into a rat as an allograft for 7 days. Donors were pre-treated with a solution of the impermeant gluconate or a saline control immediately after cardiac death. Livers were retrieved after 30 minutes. Results: In-vivo, gluconate-infused in donors immediately before or after cardiac death prevented DCD induced increases in total tissue water (TTW), decreased vascular resistance, increased oxygen consumption and ATP synthesis, increased bile production, decreased LDH release, and decreased histology injury scores after reperfusion on the IPL relative to saline-treated DCD controls. In the transplant model, donor gluconate pretreatment significantly decreased both ALT the first day after transplantation and total bilirubin the seventh day after transplantation. Conclusions: Cell and tissue swelling plays a key role in preservation injury of uncontrolled DCD livers, which can be mitigated by early administration of gluconate solutions to the donor immediately after death. äDonor Gluconate Rescues Livers from Uncontrolled Donation after Cardia(epmc).pdf DeepDyve Pubget Overpricing