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10.1038/nbt.3427 http://scihub22266oqcxt.onion/10.1038/nbt.3427 C4744113!4744113!26655495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26655495&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2016 ; 34 (2): 164-6 Nephropedia Template TP {{tp|p=26655495|t=2016. Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay |pdf=|usr=}}{{26655495}} gab.com Text Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26655495 #FOAvip Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies. Here, we report a gene-specific method of NMD inhibition using antisense oligonucleotides (ASOs), and combine this approach with an RTC to effectively restore the expression of full-length protein from a nonsense-mutant allele. Twit Text FOAVip Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26655495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26655495 #FOAvip English Wikipedia <ref>{{Cite pmid|26655495}}</ref> Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay #MMPMID26655495 Nomakuchi TT; Rigo F; Aznarez I; Krainer AR Nat Biotechnol 2016[Feb]; 34 (2): 164-6 PMID26655495show ga Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies. Here, we report a gene-specific method of NMD inhibition using antisense oligonucleotides (ASOs), and combine this approach with an RTC to effectively restore the expression of full-length protein from a nonsense-mutant allele. äAntisense-oligonucleotide-directed inhibition of nonsense-mediated mRN(epmc).pdf DeepDyve Pubget Overpricing