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10.1146/annurev-genet-120213-092023 http://scihub22266oqcxt.onion/10.1146/annurev-genet-120213-092023 C4743252!4743252 !26473382     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26473382 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Genet 2015 ; 49 (ä): 213-42 Nephropedia Template TP {{tp|p=26473382 |t=2015. A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome |pdf=|usr=}}{{26473382 }} gab.com Text A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome JO: Annu Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26473382 #FOAvip Although microRNAs (miRNAs) are among the most intensively studied molecules of the past 20 years, determining what is and what is not a miRNA has not been straightforward. Here, we present a uniform system for the annotation and nomenclature of miRNA genes. We show that less than a third of the 1,881 human miRBase entries, and only approximately 16% of the 7,095 metazoan miRBase entries, are robustly supported as miRNA genes. Furthermore, we show that the human repertoire of miRNAs has been shaped by periods of intense miRNA innovation and that mature gene products show a very different tempo and mode of sequence evolution than star products. We establish a new open access database--MirGeneDB ( http://mirgenedb.org )--to catalog this set of miRNAs, which complements the efforts of miRBase but differs from it by annotating the mature versus star products and by imposing an evolutionary hierarchy upon this curated and consistently named repertoire. Twit Text FOAVip A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome ????Annu Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26473382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26473382 #FOAvip English Wikipedia <ref>{{Cite pmid|26473382 }}</ref> A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome #MMPMID26473382 Fromm B ; Billipp T ; Peck LE ; Johansen M ; Tarver JE ; King BL ; Newcomb JM ; Sempere LF ; Flatmark K ; Hovig E ; Peterson KJ Annu Rev Genet 2015[]; 49 (ä): 213-42 PMID26473382 show ga Although microRNAs (miRNAs) are among the most intensively studied molecules of the past 20 years, determining what is and what is not a miRNA has not been straightforward. Here, we present a uniform system for the annotation and nomenclature of miRNA genes. We show that less than a third of the 1,881 human miRBase entries, and only approximately 16% of the 7,095 metazoan miRBase entries, are robustly supported as miRNA genes. Furthermore, we show that the human repertoire of miRNAs has been shaped by periods of intense miRNA innovation and that mature gene products show a very different tempo and mode of sequence evolution than star products. We establish a new open access database--MirGeneDB ( http://mirgenedb.org )--to catalog this set of miRNAs, which complements the efforts of miRBase but differs from it by annotating the mature versus star products and by imposing an evolutionary hierarchy upon this curated and consistently named repertoire. |*Biological Evolution [MESH] |Animals [MESH] |Databases, Genetic [MESH] |Evolution, Molecular [MESH] |Humans [MESH] |MicroRNAs/*genetics [MESH] |Molecular Sequence Annotation/*methods [MESH] |Terminology as Topic [MESH]A Uniform System for the Annotation of Vertebrate microRNA Genes and t(epmc).pdf DeepDyve Pubget Overpricing