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10.1038/ncomms10549 http://scihub22266oqcxt.onion/10.1038/ncomms10549 C4742980!4742980 !26842758     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26842758 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability |pdf=|usr=}}{{26842758 }} gab.com Text Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26842758 #FOAvip Topoisomerase 1, an enzyme that relieves superhelical tension, is implicated in transcription-associated mutagenesis and genome instability-associated with neurodegenerative diseases as well as activation-induced cytidine deaminase. From proteomic analysis of TOP1-associated proteins, we identify SMARCA4, an ATP-dependent chromatin remodeller; FACT, a histone chaperone; and H3K4me3, a transcriptionally active chromatin marker. Here we show that SMARCA4 knockdown in a B-cell line decreases TOP1 recruitment to chromatin, and leads to increases in Igh/c-Myc chromosomal translocations, variable and switch region mutations and negative superhelicity, all of which are also observed in response to TOP1 knockdown. In contrast, FACT knockdown inhibits association of TOP1 with H3K4me3, and severely reduces DNA cleavage and Igh/c-Myc translocations, without significant effect on TOP1 recruitment to chromatin. We thus propose that SMARCA4 is involved in the TOP1 recruitment to general chromatin, whereas FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. Twit Text FOAVip Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26842758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26842758 #FOAvip English Wikipedia <ref>{{Cite pmid|26842758 }}</ref> Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability #MMPMID26842758 Husain A ; Begum NA ; Taniguchi T ; Taniguchi H ; Kobayashi M ; Honjo T Nat Commun 2016[Feb]; 7 (ä): 10549 PMID26842758 show ga Topoisomerase 1, an enzyme that relieves superhelical tension, is implicated in transcription-associated mutagenesis and genome instability-associated with neurodegenerative diseases as well as activation-induced cytidine deaminase. From proteomic analysis of TOP1-associated proteins, we identify SMARCA4, an ATP-dependent chromatin remodeller; FACT, a histone chaperone; and H3K4me3, a transcriptionally active chromatin marker. Here we show that SMARCA4 knockdown in a B-cell line decreases TOP1 recruitment to chromatin, and leads to increases in Igh/c-Myc chromosomal translocations, variable and switch region mutations and negative superhelicity, all of which are also observed in response to TOP1 knockdown. In contrast, FACT knockdown inhibits association of TOP1 with H3K4me3, and severely reduces DNA cleavage and Igh/c-Myc translocations, without significant effect on TOP1 recruitment to chromatin. We thus propose that SMARCA4 is involved in the TOP1 recruitment to general chromatin, whereas FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. |Animals [MESH] |B-Lymphocytes [MESH] |Cell Cycle Proteins/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Chromatin Assembly and Disassembly/genetics [MESH] |Chromatin Immunoprecipitation [MESH] |Chromatin/*metabolism [MESH] |DNA Breaks, Double-Stranded [MESH] |DNA Cleavage [MESH] |DNA Helicases/*genetics/metabolism [MESH] |DNA Topoisomerases, Type I/*genetics/metabolism [MESH] |DNA-Binding Proteins/genetics/metabolism [MESH] |Flow Cytometry [MESH] |Gene Knockdown Techniques [MESH] |Genes, Immunoglobulin Heavy Chain [MESH] |Genes, myc [MESH] |Genomic Instability/*genetics [MESH] |High Mobility Group Proteins/genetics/metabolism [MESH] |Histone Chaperones/*genetics/metabolism [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |Mice [MESH] |Nuclear Proteins/*genetics/metabolism [MESH] |Proteome [MESH] |Transcription Factors/*genetics/metabolism [MESH] |Transcription, Genetic [MESH] |Transcriptional Elongation Factors/genetics/metabolism [MESH]Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses (epmc).pdf DeepDyve Pubget Overpricing