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10.1038/ncomms10517 http://scihub22266oqcxt.onion/10.1038/ncomms10517 C4742920!4742920!26841680     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26841680|t=2016. Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer |pdf=|usr=}}{{26841680}} gab.com Text Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26841680 #FOAvip CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit could promote procarcinogenic inflammation and altered tumour immunity. Here we show that splenic TFF2, a secreted anti-inflammatory peptide, is released by vagally modulated memory T cells to suppress the expansion of MDSCs through CXCR4. Splenic denervation interrupts the anti-inflammatory neural arc, resulting in the expansion of MDSCs and colorectal cancer. Deletion of Tff2 recapitulates splenic denervation to promote carcinogenesis. Colorectal carcinogenesis could be suppressed through transgenic overexpression of TFF2, adenoviral transfer of TFF2 or transplantation of TFF2-expressing bone marrow. TFF2 is important to the anti-inflammatory reflex arc and plays an essential role in arresting MDSC proliferation. TFF2 offers a potential approach to prevent and to treat cancer. Twit Text FOAVip Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26841680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26841680 #FOAvip English Wikipedia <ref>{{Cite pmid|26841680}}</ref> Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer #MMPMID26841680 Dubeykovskaya Z; Si Y; Chen X; Worthley DL; Renz BW; Urbanska AM; Hayakawa Y; Xu T; Westphalen CB; Dubeykovskiy A; Chen D; Friedman RA; Asfaha S; Nagar K; Tailor Y; Muthupalani S; Fox JG; Kitajewski J; Wang TC Nat Commun 2016[]; 7 (ä): ä PMID26841680show ga CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit could promote procarcinogenic inflammation and altered tumour immunity. Here we show that splenic TFF2, a secreted anti-inflammatory peptide, is released by vagally modulated memory T cells to suppress the expansion of MDSCs through CXCR4. Splenic denervation interrupts the anti-inflammatory neural arc, resulting in the expansion of MDSCs and colorectal cancer. Deletion of Tff2 recapitulates splenic denervation to promote carcinogenesis. Colorectal carcinogenesis could be suppressed through transgenic overexpression of TFF2, adenoviral transfer of TFF2 or transplantation of TFF2-expressing bone marrow. TFF2 is important to the anti-inflammatory reflex arc and plays an essential role in arresting MDSC proliferation. TFF2 offers a potential approach to prevent and to treat cancer. äNeural innervation stimulates splenic TFF2 to arrest myeloid cell expa(epmc).pdf DeepDyve Pubget Overpricing