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10.1038/ncomms10339 http://scihub22266oqcxt.onion/10.1038/ncomms10339 C4742836!4742836 !26842342     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26842342 &cmd=llinks): Failed to open stream: HTTP request failed! 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A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis |pdf=|usr=}}{{26842342 }} gab.com Text A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26842342 #FOAvip Two-pore domain potassium (K2P) channels act to maintain cell resting membrane potential--a prerequisite for many biological processes. KCNK9, a member of K2P family, is implicated in cancer, owing to its overexpression in human tumours and its ability to promote neoplastic cell survival and growth. However, KCNK9's underlying contributions to malignancy remain elusive due to the absence of specific modulators. Here we describe the development of monoclonal antibodies against the KCNK9 extracellular domain and their functional effects. We show that one antibody (Y4) with the highest affinity binding induces channel internalization. The addition of Y4 to KCNK9-expressing carcinoma cells reduces cell viability and increases cell death. Systemic administration of Y4 effectively inhibits growth of human lung cancer xenografts and murine breast cancer metastasis in mice. Evidence for Y4-mediated carcinoma cell autonomous and immune-dependent cytotoxicity is presented. Our study reveals that antibody-based KCNK9 targeting is a promising therapeutic strategy in KCNK9-expressing malignancies. Twit Text FOAVip A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26842342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26842342 #FOAvip English Wikipedia <ref>{{Cite pmid|26842342 }}</ref> A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis #MMPMID26842342 Sun H ; Luo L ; Lal B ; Ma X ; Chen L ; Hann CL ; Fulton AM ; Leahy DJ ; Laterra J ; Li M Nat Commun 2016[Feb]; 7 (ä): 10339 PMID26842342 show ga Two-pore domain potassium (K2P) channels act to maintain cell resting membrane potential--a prerequisite for many biological processes. KCNK9, a member of K2P family, is implicated in cancer, owing to its overexpression in human tumours and its ability to promote neoplastic cell survival and growth. However, KCNK9's underlying contributions to malignancy remain elusive due to the absence of specific modulators. Here we describe the development of monoclonal antibodies against the KCNK9 extracellular domain and their functional effects. We show that one antibody (Y4) with the highest affinity binding induces channel internalization. The addition of Y4 to KCNK9-expressing carcinoma cells reduces cell viability and increases cell death. Systemic administration of Y4 effectively inhibits growth of human lung cancer xenografts and murine breast cancer metastasis in mice. Evidence for Y4-mediated carcinoma cell autonomous and immune-dependent cytotoxicity is presented. Our study reveals that antibody-based KCNK9 targeting is a promising therapeutic strategy in KCNK9-expressing malignancies. |Animals [MESH] |Antibodies, Monoclonal/*pharmacology [MESH] |Apoptosis/*drug effects [MESH] |Blotting, Western [MESH] |COS Cells [MESH] |Cell Cycle [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/*drug effects [MESH] |Cell Survival/drug effects [MESH] |Chlorocebus aethiops [MESH] |Drug Screening Assays, Antitumor [MESH] |Flow Cytometry [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |In Vitro Techniques [MESH] |Membrane Potentials/drug effects [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Microscopy, Confocal [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Transplantation [MESH] |Neoplasms/genetics/*metabolism/pathology [MESH] |Potassium Channels, Tandem Pore Domain/*antagonists & inhibitors/genetics/metabolism [MESH] |Protein Structure, Tertiary [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]A monoclonal antibody against KCNK9 K(+) channel extracellular domain (epmc).pdf DeepDyve Pubget Overpricing