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10.1038/ncomms10539 http://scihub22266oqcxt.onion/10.1038/ncomms10539 C4742834!4742834!26837714     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26837714|t=2016. Epigenetic re-expression of HIF-2? suppresses soft tissue sarcoma growth |pdf=|usr=}}{{26837714}} gab.com Text Epigenetic re-expression of HIF-2 suppresses soft tissue sarcoma growth JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26837714 #FOAvip In soft tissue sarcomas (STS), low intratumoural O2 (hypoxia) is a poor prognostic indicator. HIF-1? mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2? protein is unknown. Surprisingly, here we show that HIF-2? inhibits high-grade STS cell growth in vivo, as loss of HIF-2? promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. We find that most human STS have lower levels of EPAS1 (the gene encoding HIF-2?) expression relative to normal tissue. Many cancers, including STS, contain altered epigenetics, and our findings define an epigenetic mechanism whereby EPAS1 is silenced during sarcoma progression. The clinically approved HDAC inhibitor Vorinostat specifically increases HIF-2?, but not HIF-1?, accumulation in multiple STS subtypes. Vorinostat inhibits STS tumour growth, an effect ameliorated by HIF-2? deletion, implicating HIF-2? as a biomarker for Vorinostat efficacy in STS. Twit Text FOAVip Epigenetic re-expression of HIF-2 suppresses soft tissue sarcoma growth ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26837714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26837714 #FOAvip English Wikipedia <ref>{{Cite pmid|26837714}}</ref> Epigenetic re-expression of HIF-2? suppresses soft tissue sarcoma growth #MMPMID26837714 Nakazawa MS; Eisinger-Mathason TSK; Sadri N; Ochocki JD; Gade TPF; Amin RK; Simon MC Nat Commun 2016[]; 7 (ä): ä PMID26837714show ga In soft tissue sarcomas (STS), low intratumoural O2 (hypoxia) is a poor prognostic indicator. HIF-1? mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2? protein is unknown. Surprisingly, here we show that HIF-2? inhibits high-grade STS cell growth in vivo, as loss of HIF-2? promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. We find that most human STS have lower levels of EPAS1 (the gene encoding HIF-2?) expression relative to normal tissue. Many cancers, including STS, contain altered epigenetics, and our findings define an epigenetic mechanism whereby EPAS1 is silenced during sarcoma progression. The clinically approved HDAC inhibitor Vorinostat specifically increases HIF-2?, but not HIF-1?, accumulation in multiple STS subtypes. Vorinostat inhibits STS tumour growth, an effect ameliorated by HIF-2? deletion, implicating HIF-2? as a biomarker for Vorinostat efficacy in STS. äEpigenetic re-expression of HIF-2? suppresses soft tissue sarcoma grow(epmc).pdf DeepDyve Pubget Overpricing