LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression
by sponging miR-200s in clear cell kidney carcinoma
#MMPMID26461224
Xiao H
; Tang K
; Liu P
; Chen K
; Hu J
; Zeng J
; Xiao W
; Yu G
; Yao W
; Zhou H
; Li H
; Pan Y
; Li A
; Ye Z
; Wang J
; Xu H
; Huang Q
Oncotarget
2015[Nov]; 6
(35
): 38005-15
PMID26461224
show ga
Long non-coding RNA (lncRNAs) play a critical role in the development of cancers.
LncRNA metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has
recently been identified to be involved in tumorigenesis of several cancers such
as lung cancer, bladder cancer and so on. Here, we found that MALAT1 exist a
higher fold change (Tumor/Normal) in clear cell kidney carcinoma (KIRC) from The
Cancer Genome Atlas (TCGA) Data Portal and a negative correlation with miR-200s
family. We further demonstrated MALAT1 promote KIRC proliferation and metastasis
through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly
reverse the MALAT1's stimulation on proliferation and metastasis in KIRC. In
summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the
progression of KIRC. The inhibition of MALAT1 expression may be a promising
strategy for KIRC therapy.
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