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10.18632/oncotarget.6063 http://scihub22266oqcxt.onion/10.18632/oncotarget.6063 C4741946!4741946 !26462028     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26462028 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (35 ): 37526-43 Nephropedia Template TP {{tp|p=26462028 |t=2015. Combinatorial TGF-? attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells |pdf=|usr=}}{{26462028 }} gab.com Text Combinatorial TGF- attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26462028 #FOAvip Distant relapse after chemotherapy is an important clinical issue for treating breast cancer patients and results from the development of cancer stem-like cells (CSCs) during chemotherapy. Here we report that blocking epithelial-to-mesenchymal transition (EMT) suppresses paclitaxel-induced CSCs properties by using a MDA-MB-231-xenografted mice model (in vivo), and breast cancer cell lines (in vitro). Paclitaxel, one of the cytotoxic taxane-drugs such as docetaxel, increases mesenchymal markers (Vimentin and Fibronectin) and decreases an epithelial marker (Zo-1). Blocking TGF-? signaling with the TGF-? type I receptor kinase (ALK5) inhibitor, EW-7197, suppresses paclitaxel-induced EMT and CSC properties such as mammosphere-forming efficiency (MSFE), aldehyde dehydrogenase (ALDH) activity, CD44+/CD24- ratio, and pluripotency regulators (Oct4, Nanog, Klf4, Myc, and Sox2). The combinatorial treatment of EW-7197 improves the therapeutic effect of paclitaxel by decreasing the lung metastasis and increasing the survival time in vivo. We confirmed that Snail is increased by paclitaxel-induced intracellular reactive oxygen species (ROS) and EW-7197 suppresses the paclitaxel-induced Snail and EMT by attenuating paclitaxel-induced intracellular ROS. Knock-down of SNAI1 suppresses paclitaxel-induced EMT and CSC properties. These data together suggest that blocking the Snail-induced EMT with the ALK5 inhibitor attenuates metastasis after paclitaxel-therapy and that this combinatorial approach could prove useful in treating breast cancer. Twit Text FOAVip Combinatorial TGF- attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26462028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26462028 #FOAvip English Wikipedia <ref>{{Cite pmid|26462028 }}</ref> Combinatorial TGF-? attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells #MMPMID26462028 Park SY ; Kim MJ ; Park SA ; Kim JS ; Min KN ; Kim DK ; Lim W ; Nam JS ; Sheen YY Oncotarget 2015[Nov]; 6 (35 ): 37526-43 PMID26462028 show ga Distant relapse after chemotherapy is an important clinical issue for treating breast cancer patients and results from the development of cancer stem-like cells (CSCs) during chemotherapy. Here we report that blocking epithelial-to-mesenchymal transition (EMT) suppresses paclitaxel-induced CSCs properties by using a MDA-MB-231-xenografted mice model (in vivo), and breast cancer cell lines (in vitro). Paclitaxel, one of the cytotoxic taxane-drugs such as docetaxel, increases mesenchymal markers (Vimentin and Fibronectin) and decreases an epithelial marker (Zo-1). Blocking TGF-? signaling with the TGF-? type I receptor kinase (ALK5) inhibitor, EW-7197, suppresses paclitaxel-induced EMT and CSC properties such as mammosphere-forming efficiency (MSFE), aldehyde dehydrogenase (ALDH) activity, CD44+/CD24- ratio, and pluripotency regulators (Oct4, Nanog, Klf4, Myc, and Sox2). The combinatorial treatment of EW-7197 improves the therapeutic effect of paclitaxel by decreasing the lung metastasis and increasing the survival time in vivo. We confirmed that Snail is increased by paclitaxel-induced intracellular reactive oxygen species (ROS) and EW-7197 suppresses the paclitaxel-induced Snail and EMT by attenuating paclitaxel-induced intracellular ROS. Knock-down of SNAI1 suppresses paclitaxel-induced EMT and CSC properties. These data together suggest that blocking the Snail-induced EMT with the ALK5 inhibitor attenuates metastasis after paclitaxel-therapy and that this combinatorial approach could prove useful in treating breast cancer. |Animals [MESH] |Antineoplastic Agents, Phytogenic/pharmacology [MESH] |Blotting, Western [MESH] |Breast Neoplasms/drug therapy/metabolism/pathology/*prevention & control [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Combined Modality Therapy [MESH] |Drug Resistance, Neoplasm [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Humans [MESH] |Kruppel-Like Factor 4 [MESH] |Lung Neoplasms/drug therapy/metabolism/*prevention & control/secondary [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Neoplastic Stem Cells/*drug effects/metabolism/pathology [MESH] |Paclitaxel/*pharmacology [MESH] |RNA, Messenger/genetics [MESH] |RNA, Small Interfering/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Transforming Growth Factor beta/*antagonists & inhibitors/genetics [MESH] |Tumor Cells, Cultured [MESH] |Wound Healing [MESH]Combinatorial TGF-? attenuation with paclitaxel inhibits the epithel(epmc).pdf DeepDyve Pubget Overpricing