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10.18632/oncotarget.5076 http://scihub22266oqcxt.onion/10.18632/oncotarget.5076 C4741919!4741919 !26359351     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26359351 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling |pdf=|usr=}}{{26359351 }} gab.com Text Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26359351 #FOAvip Adenoid cystic carcinoma (ACC) is a rare cancer with high potential for recurrence and metastasis. Efficacy of current treatment options, particularly for advanced disease, is very limited. Recent whole genome and exome sequencing has dramatically improved our understanding of ACC pathogenesis. A balanced translocation resulting in the MYB-NFIB fusion gene appears to be a fundamental signature of ACC. In addition, sequencing has identified a number of other driver genes mutated in downstream pathways common to other well-studied cancers. Overexpression of oncogenic proteins involved in cell growth, adhesion, cell cycle regulation, and angiogenesis are also present in ACC. Collectively, studies have identified genes and proteins for targeted, mechanism-based, therapies based on tumor phenotypes, as opposed to nonspecific cytotoxic agents. In addition, although few studies in ACC currently exist, immunotherapy may also hold promise. Better genetic understanding will enable treatment with novel targeted agents and initial exploration of immune-based therapies with the goal of improving outcomes for patients with ACC. Twit Text FOAVip Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26359351 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26359351 #FOAvip English Wikipedia <ref>{{Cite pmid|26359351 }}</ref> Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling #MMPMID26359351 Chae YK ; Chung SY ; Davis AA ; Carneiro BA ; Chandra S ; Kaplan J ; Kalyan A ; Giles FJ Oncotarget 2015[Nov]; 6 (35 ): 37117-34 PMID26359351 show ga Adenoid cystic carcinoma (ACC) is a rare cancer with high potential for recurrence and metastasis. Efficacy of current treatment options, particularly for advanced disease, is very limited. Recent whole genome and exome sequencing has dramatically improved our understanding of ACC pathogenesis. A balanced translocation resulting in the MYB-NFIB fusion gene appears to be a fundamental signature of ACC. In addition, sequencing has identified a number of other driver genes mutated in downstream pathways common to other well-studied cancers. Overexpression of oncogenic proteins involved in cell growth, adhesion, cell cycle regulation, and angiogenesis are also present in ACC. Collectively, studies have identified genes and proteins for targeted, mechanism-based, therapies based on tumor phenotypes, as opposed to nonspecific cytotoxic agents. In addition, although few studies in ACC currently exist, immunotherapy may also hold promise. Better genetic understanding will enable treatment with novel targeted agents and initial exploration of immune-based therapies with the goal of improving outcomes for patients with ACC. |*Gene Expression Profiling [MESH] |*Molecular Targeted Therapy [MESH] |Carcinoma, Adenoid Cystic/genetics/*therapy [MESH] |Humans [MESH]Adenoid cystic carcinoma: current therapy and potential therapeutic ad(epmc).pdf DeepDyve Pubget Overpricing