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10.18632/oncotarget.4893 http://scihub22266oqcxt.onion/10.18632/oncotarget.4893 C4741762!4741762 !26356817     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26356817 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (32 ): 33237-52 Nephropedia Template TP {{tp|p=26356817 |t=2015. An epigenetic auto-feedback loop regulates TGF-? type II receptor expression and function in NSCLC |pdf=|usr=}}{{26356817 }} gab.com Text An epigenetic auto-feedback loop regulates TGF- type II receptor expression and function in NSCLC JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26356817 #FOAvip The downregulation of transforming growth factor-? (TGF-?) type II receptor (T?RII) expression and function plays a pivotal role in the loss of the TGF-?-induced tumor suppressor function that contributes to lung cancer progression. The aberrant expression of miRNAs has been shown to be involved in the regulation of oncogenes and tumor suppressor genes. Our current study involving miRNA microarray, northern blot and QRT-PCR analysis shows an inverse correlation between miR-20a and T?RII expression in non-small cell lung cancer (NSCLC) tissues and cell lines. Stable expression of miR-20a downregulates T?RII in lung epithelial cells which results in an inhibition of TGF-? signaling and attenuation of TGF-?-induced cell growth suppression and apoptosis. Stable knock down of miR-20a increases T?RII expression and inhibits tumorigenicity of lung cancer cells in vivo. Oncogene c-Myc promotes miR-20a expression by activating its promoter leading to downregulation of T?RII expression and TGF-ß signaling. MiR-145, which is upregulated by TGF-?, inhibits miR-20a expression by targeting c-Myc and upregulates T?RII expression. These correlations among miRNAs and cellular proteins are supported by TCGA public database using NSCLC specimens. These results suggest a novel mechanism for the loss of T?RII expression and TGF-?-induced tumor suppressor functions in lung cancer through a complex auto-feedback loop TGF-?/miR-145/c-Myc/miR-20a/T?RII. Twit Text FOAVip An epigenetic auto-feedback loop regulates TGF- type II receptor expression and function in NSCLC ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26356817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26356817 #FOAvip English Wikipedia <ref>{{Cite pmid|26356817 }}</ref> An epigenetic auto-feedback loop regulates TGF-? type II receptor expression and function in NSCLC #MMPMID26356817 Yang S ; Cho YJ ; Jin L ; Yuan G ; Datta A ; Buckhaults P ; Datta PK Oncotarget 2015[Oct]; 6 (32 ): 33237-52 PMID26356817 show ga The downregulation of transforming growth factor-? (TGF-?) type II receptor (T?RII) expression and function plays a pivotal role in the loss of the TGF-?-induced tumor suppressor function that contributes to lung cancer progression. The aberrant expression of miRNAs has been shown to be involved in the regulation of oncogenes and tumor suppressor genes. Our current study involving miRNA microarray, northern blot and QRT-PCR analysis shows an inverse correlation between miR-20a and T?RII expression in non-small cell lung cancer (NSCLC) tissues and cell lines. Stable expression of miR-20a downregulates T?RII in lung epithelial cells which results in an inhibition of TGF-? signaling and attenuation of TGF-?-induced cell growth suppression and apoptosis. Stable knock down of miR-20a increases T?RII expression and inhibits tumorigenicity of lung cancer cells in vivo. Oncogene c-Myc promotes miR-20a expression by activating its promoter leading to downregulation of T?RII expression and TGF-ß signaling. MiR-145, which is upregulated by TGF-?, inhibits miR-20a expression by targeting c-Myc and upregulates T?RII expression. These correlations among miRNAs and cellular proteins are supported by TCGA public database using NSCLC specimens. These results suggest a novel mechanism for the loss of T?RII expression and TGF-?-induced tumor suppressor functions in lung cancer through a complex auto-feedback loop TGF-?/miR-145/c-Myc/miR-20a/T?RII. |*Epigenesis, Genetic [MESH] |*Gene Expression Regulation, Neoplastic [MESH] |Carcinoma, Non-Small-Cell Lung/*genetics/pathology [MESH] |Feedback, Physiological/physiology [MESH] |Genes, myc/physiology [MESH] |Humans [MESH] |Lung Neoplasms/*genetics/pathology [MESH] |MicroRNAs/physiology [MESH] |Protein Serine-Threonine Kinases/*genetics/*physiology [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/*genetics/*physiology [MESH]An epigenetic auto-feedback loop regulates TGF-? type II receptor expr(epmc).pdf DeepDyve Pubget Overpricing