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http://scihub22266oqcxt.onion/ C4741737!4741737!26413750     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (32): 32890-901 Nephropedia Template TP {{tp|p=26413750|t=2015. LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression |pdf=|usr=}}{{26413750}} gab.com Text LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26413750 #FOAvip Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms of CRC pathogenesis are not fully understood. In this study, we report the characterization of LYAR (Ly-1 antibody reactive clone) as a key regulator of the migration and invasion of human CRC cells. Immunohistochemistry analysis demonstrated that LYAR is expressed at a higher level in metastatic CRC tissues. We found that LYAR promoted the migratory and invasive capabilities of CRC cells. Gene expression profile analysis of CRC cells showed that LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR. The ChIP assay and gene reporter assays indicated that LYAR directly bound to the LGALS1 promoter. The ectopic expression of galectin-1 partially restored the mobile potential of LYAR knocked-down cells, which suggests that galectin-1 contributed to the LYAR-promoted cell migration and invasion of CRC cells. Thus, this study revealed a novel mechanism by which the transcription factor LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in CRC. Twit Text FOAVip LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26413750 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26413750 #FOAvip English Wikipedia <ref>{{Cite pmid|26413750}}</ref> LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression #MMPMID26413750 Wu Y; Liu M; Li Z; Wu XB; Wang Y; Wang Y; Nie M; Huang F; Ju J; Ma C; Tan R; Zen K; Zhang CY; Fu K; Chen YG; Wang MR; Zhao Q Oncotarget 2015[Oct]; 6 (32): 32890-901 PMID26413750show ga Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms of CRC pathogenesis are not fully understood. In this study, we report the characterization of LYAR (Ly-1 antibody reactive clone) as a key regulator of the migration and invasion of human CRC cells. Immunohistochemistry analysis demonstrated that LYAR is expressed at a higher level in metastatic CRC tissues. We found that LYAR promoted the migratory and invasive capabilities of CRC cells. Gene expression profile analysis of CRC cells showed that LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR. The ChIP assay and gene reporter assays indicated that LYAR directly bound to the LGALS1 promoter. The ectopic expression of galectin-1 partially restored the mobile potential of LYAR knocked-down cells, which suggests that galectin-1 contributed to the LYAR-promoted cell migration and invasion of CRC cells. Thus, this study revealed a novel mechanism by which the transcription factor LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in CRC. äLYAR promotes colorectal cancer cell mobility by activating galectin-1(epmc).pdf DeepDyve Pubget Overpricing