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10.18632/oncotarget.5289 http://scihub22266oqcxt.onion/10.18632/oncotarget.5289 C4741715!4741715 !26418953     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26418953 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (32 ): 32602-9 Nephropedia Template TP {{tp|p=26418953 |t=2015. Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology |pdf=|usr=}}{{26418953 }} gab.com Text Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26418953 #FOAvip Tumor sequencing has revolutionized oncology, allowing for detailed interrogation of the molecular underpinnings of cancer at an individual level. With this additional insight, it is increasingly apparent that not only do tumors vary within a sample (tumor heterogeneity), but also that each patient's individual tumor is a constellation of unique molecular aberrations that will require an equally unique personalized therapeutic regimen. We report here the results of 439 patients who underwent Clinical Laboratory Improvement Amendment (CLIA)-certified next generation sequencing (NGS) across histologies. Among these patients, 98.4% had a unique molecular profile, and aside from three primary brain tumor patients with a single genetic lesion (IDH1 R132H), no two patients within a given histology were molecularly identical. Additionally, two sets of patients had identical profiles consisting of two mutations in common and no other anomalies. However, these profiles did not segregate by histology (lung adenocarcinoma-appendiceal cancer (KRAS G12D and GNAS R201C), and lung adenocarcinoma-liposarcoma (CDK4 and MDM2 amplification pairs)). These findings suggest that most advanced tumors are molecular singletons within and between histologies, and that tumors that differ in histology may still nonetheless exhibit identical molecular portraits, albeit rarely. Twit Text FOAVip Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26418953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26418953 #FOAvip English Wikipedia <ref>{{Cite pmid|26418953 }}</ref> Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology #MMPMID26418953 Patel SP ; Schwaederle M ; Daniels GA ; Fanta PT ; Schwab RB ; Shimabukuro KA ; Kesari S ; Piccioni DE ; Bazhenova LA ; Helsten TL ; Lippman SM ; Parker BA ; Kurzrock R Oncotarget 2015[Oct]; 6 (32 ): 32602-9 PMID26418953 show ga Tumor sequencing has revolutionized oncology, allowing for detailed interrogation of the molecular underpinnings of cancer at an individual level. With this additional insight, it is increasingly apparent that not only do tumors vary within a sample (tumor heterogeneity), but also that each patient's individual tumor is a constellation of unique molecular aberrations that will require an equally unique personalized therapeutic regimen. We report here the results of 439 patients who underwent Clinical Laboratory Improvement Amendment (CLIA)-certified next generation sequencing (NGS) across histologies. Among these patients, 98.4% had a unique molecular profile, and aside from three primary brain tumor patients with a single genetic lesion (IDH1 R132H), no two patients within a given histology were molecularly identical. Additionally, two sets of patients had identical profiles consisting of two mutations in common and no other anomalies. However, these profiles did not segregate by histology (lung adenocarcinoma-appendiceal cancer (KRAS G12D and GNAS R201C), and lung adenocarcinoma-liposarcoma (CDK4 and MDM2 amplification pairs)). These findings suggest that most advanced tumors are molecular singletons within and between histologies, and that tumors that differ in histology may still nonetheless exhibit identical molecular portraits, albeit rarely. |*DNA Mutational Analysis [MESH] |*Gene Expression Profiling/methods [MESH] |*Mutation [MESH] |*Precision Medicine [MESH] |Biomarkers, Tumor/*genetics [MESH] |Computational Biology [MESH] |Databases, Genetic [MESH] |Female [MESH] |Genetic Predisposition to Disease [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasms/drug therapy/genetics/*pathology [MESH] |Patient Selection [MESH] |Phenotype [MESH] |Predictive Value of Tests [MESH]Molecular inimitability amongst tumors: implications for precision can(epmc).pdf DeepDyve Pubget Overpricing