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10.18632/oncotarget.5309 http://scihub22266oqcxt.onion/10.18632/oncotarget.5309 C4741714!4741714 !26452129     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26452129 &cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2 |pdf=|usr=}}{{26452129 }} gab.com Text MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26452129 #FOAvip Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of colon cancer, but the roles of microRNA-506 (miR-506) in colon cancer remain elusive. Here, we demonstrated that miR-506 was down-regulated in colon cancer tissue and cells and that miR-506 expression was inversely correlated with EZH2 expression, tumor size, lymph node invasion, TNM stage and metastasis. A high level of miR-506 identified patients with a favorable prognosis. In vitro and in vivo experiments confirmed that miR-506 inhibits the proliferation and metastasis of colon cancer, and a luciferase reporter assay confirmed that EZH2 is a direct and functional target of miR-506 via the 3'UTR of EZH2. The restoration of EZH2 expression partially reversed the proliferation and invasion of miR-506-overexpressing colon cancer cells. Moreover, we confirmed that the miR-506-EZH2 axis inhibits proliferation and metastasis by activating/suppressing specific downstream tumor-associated genes and the Wnt/?-catenin signaling pathway. Taking together, our study sheds light on the role of miR-506 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-506 may serve as a new potential marker for monitoring and treating colon cancer. Twit Text FOAVip MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26452129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26452129 #FOAvip English Wikipedia <ref>{{Cite pmid|26452129 }}</ref> MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2 #MMPMID26452129 Zhang Y ; Lin C ; Liao G ; Liu S ; Ding J ; Tang F ; Wang Z ; Liang X ; Li B ; Wei Y ; Huang Q ; Li X ; Tang B Oncotarget 2015[Oct]; 6 (32 ): 32586-601 PMID26452129 show ga Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of colon cancer, but the roles of microRNA-506 (miR-506) in colon cancer remain elusive. Here, we demonstrated that miR-506 was down-regulated in colon cancer tissue and cells and that miR-506 expression was inversely correlated with EZH2 expression, tumor size, lymph node invasion, TNM stage and metastasis. A high level of miR-506 identified patients with a favorable prognosis. In vitro and in vivo experiments confirmed that miR-506 inhibits the proliferation and metastasis of colon cancer, and a luciferase reporter assay confirmed that EZH2 is a direct and functional target of miR-506 via the 3'UTR of EZH2. The restoration of EZH2 expression partially reversed the proliferation and invasion of miR-506-overexpressing colon cancer cells. Moreover, we confirmed that the miR-506-EZH2 axis inhibits proliferation and metastasis by activating/suppressing specific downstream tumor-associated genes and the Wnt/?-catenin signaling pathway. Taking together, our study sheds light on the role of miR-506 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-506 may serve as a new potential marker for monitoring and treating colon cancer. |*Cell Movement [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Biomarkers, Tumor/genetics/*metabolism [MESH] |Cell Proliferation [MESH] |Colonic Neoplasms/*enzymology/genetics/mortality/pathology/therapy [MESH] |Enhancer of Zeste Homolog 2 Protein [MESH] |Female [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HCT116 Cells [MESH] |HEK293 Cells [MESH] |HT29 Cells [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Middle Aged [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Polycomb Repressive Complex 2/genetics/*metabolism [MESH] |RNA Interference [MESH] |Time Factors [MESH] |Transfection [MESH] |Treatment Outcome [MESH]MicroRNA-506 suppresses tumor proliferation and metastasis in colon ca(epmc).pdf DeepDyve Pubget Overpricing