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10.18632/oncotarget.5308 http://scihub22266oqcxt.onion/10.18632/oncotarget.5308 C4741498!4741498 !26472184     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26472184 &cmd=llinks): Failed to open stream: HTTP request failed! 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The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells |pdf=|usr=}}{{26472184 }} gab.com Text The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26472184 #FOAvip Host defense peptides (HDPs) are naturally occurring molecules found in most species, in which they play a significant role in the first line defense against intruding pathogens, and several HDPs have been shown to possess anticancer activity. Structure-activity relationship studies on the HDP bovine lactoferricin revealed a de novo design of a nonamer peptide LTX-315, with oncolytic properties. In the present study, we investigated the oncolytic activity of LTX-315 in human melanoma cells (A375). LTX-315 induced a rapid plasma membrane disruption and cell death within 2 hours. At a low concentration, fluorescence-labeled LTX-315 was internalized and accumulated in cytoplasmic vacuoles in close proximity to the mitochondria. The mitochondrial membrane potential was shown to depolarize as a consequence of LTX-315 treatment and at ultrastructural level, the mitochondria morphology was significantly altered. Release of danger signals (DAMPs) such as ATP, Cytochrome C and HMGB1 into the cell supernatant of cultured cells was evident minutes after peptide treatment. The oncolytic effect of LTX-315 involving perturbation of both the cell membrane and the mitochondria with subsequent release of DAMPs may highlight the ability of LTX-315 to induce complete regression and long-term protective immune responses as previously reported in experimental animal models. Twit Text FOAVip The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26472184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26472184 #FOAvip English Wikipedia <ref>{{Cite pmid|26472184 }}</ref> The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells #MMPMID26472184 Eike LM ; Yang N ; Rekdal Ø ; Sveinbjørnsson B Oncotarget 2015[Oct]; 6 (33 ): 34910-23 PMID26472184 show ga Host defense peptides (HDPs) are naturally occurring molecules found in most species, in which they play a significant role in the first line defense against intruding pathogens, and several HDPs have been shown to possess anticancer activity. Structure-activity relationship studies on the HDP bovine lactoferricin revealed a de novo design of a nonamer peptide LTX-315, with oncolytic properties. In the present study, we investigated the oncolytic activity of LTX-315 in human melanoma cells (A375). LTX-315 induced a rapid plasma membrane disruption and cell death within 2 hours. At a low concentration, fluorescence-labeled LTX-315 was internalized and accumulated in cytoplasmic vacuoles in close proximity to the mitochondria. The mitochondrial membrane potential was shown to depolarize as a consequence of LTX-315 treatment and at ultrastructural level, the mitochondria morphology was significantly altered. Release of danger signals (DAMPs) such as ATP, Cytochrome C and HMGB1 into the cell supernatant of cultured cells was evident minutes after peptide treatment. The oncolytic effect of LTX-315 involving perturbation of both the cell membrane and the mitochondria with subsequent release of DAMPs may highlight the ability of LTX-315 to induce complete regression and long-term protective immune responses as previously reported in experimental animal models. |Antineoplastic Agents/*pharmacology [MESH] |Cell Death [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/drug effects [MESH] |Humans [MESH] |Lactoferrin/*pharmacology [MESH] |Melanoma/*pathology [MESH] |Membrane Potential, Mitochondrial/drug effects [MESH] |Microscopy, Confocal [MESH] |Microscopy, Electron, Transmission [MESH] |Mitochondria/*drug effects [MESH] |Peptides/chemistry/pharmacology [MESH]The oncolytic peptide LTX-315 induces cell death and DAMP release by m(epmc).pdf DeepDyve Pubget Overpricing