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10.18632/oncotarget.5858 http://scihub22266oqcxt.onion/10.18632/oncotarget.5858 C4741490!4741490 !26431277     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26431277 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (33 ): 34788-99 Nephropedia Template TP {{tp|p=26431277 |t=2015. PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway |pdf=|usr=}}{{26431277 }} gab.com Text PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26431277 #FOAvip The Hippo pathway significantly correlates with organ size control and tumorigenesis. The activity of YAP/TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in cancer stem cells (CSCs). But, upstream signals that control the mammalian Hippo pathway have not been well understood. Here, we reveal a connection between the Protease-activated receptor 1 (PAR1) signaling pathway and the Hippo-YAP pathway in gastric cancer stem-like cells. The selective PAR1 agonist TFLLR-NH2 induces an increase in the fraction of side population cells which is enriched in CSCs, and promotes tumorigenesis, multi cancer drug resistance, cell morphological change, and cell invasion which are characteristics of CSCs. In addition, PAR1 activation inhibits the Hippo-YAP pathway kinase Lats via Rho GTPase. Lats kinase inhibition in turn results in increased nuclear localization of dephosphorylated YAP. Furthermore, PAR1 activation confers CSCs related traits via the Hippo-YAP pathway, and the Hippo-YAP pathway correlates with epithelial mesenchymal transition which is induced by PAR1 activation. Our research suggests that the PAR1 signaling deeply participates in the ability of multi drug resistance and tumorigenesis through interactions with the Hippo-YAP pathway signaling in gastric cancer stem-like cells. We presume that inhibited YAP is a new therapeutic target in the treatment human gastric cancer invasion and metastasis by dysregulated PAR1 or its agonists. Twit Text FOAVip PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26431277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26431277 #FOAvip English Wikipedia <ref>{{Cite pmid|26431277 }}</ref> PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway #MMPMID26431277 Fujimoto D ; Ueda Y ; Hirono Y ; Goi T ; Yamaguchi A Oncotarget 2015[Oct]; 6 (33 ): 34788-99 PMID26431277 show ga The Hippo pathway significantly correlates with organ size control and tumorigenesis. The activity of YAP/TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in cancer stem cells (CSCs). But, upstream signals that control the mammalian Hippo pathway have not been well understood. Here, we reveal a connection between the Protease-activated receptor 1 (PAR1) signaling pathway and the Hippo-YAP pathway in gastric cancer stem-like cells. The selective PAR1 agonist TFLLR-NH2 induces an increase in the fraction of side population cells which is enriched in CSCs, and promotes tumorigenesis, multi cancer drug resistance, cell morphological change, and cell invasion which are characteristics of CSCs. In addition, PAR1 activation inhibits the Hippo-YAP pathway kinase Lats via Rho GTPase. Lats kinase inhibition in turn results in increased nuclear localization of dephosphorylated YAP. Furthermore, PAR1 activation confers CSCs related traits via the Hippo-YAP pathway, and the Hippo-YAP pathway correlates with epithelial mesenchymal transition which is induced by PAR1 activation. Our research suggests that the PAR1 signaling deeply participates in the ability of multi drug resistance and tumorigenesis through interactions with the Hippo-YAP pathway signaling in gastric cancer stem-like cells. We presume that inhibited YAP is a new therapeutic target in the treatment human gastric cancer invasion and metastasis by dysregulated PAR1 or its agonists. |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Animals [MESH] |Blotting, Western [MESH] |Carcinogenesis/*metabolism [MESH] |Cell Line, Tumor [MESH] |Drug Resistance, Multiple/*physiology [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Heterografts [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Immunoprecipitation [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplastic Stem Cells/*metabolism [MESH] |Phosphoproteins/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Receptor, PAR-1/*metabolism [MESH] |Signal Transduction/physiology [MESH] |Stomach Neoplasms/metabolism/pathology [MESH] |Transcription Factors [MESH] |Transfection [MESH]PAR1 participates in the ability of multidrug resistance and tumorigen(epmc).pdf DeepDyve Pubget Overpricing