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Current Concepts in the Biochemical Mechanisms of Glaucomatous Neurodegeneration #MMPMID26997782
Shoeb Ahmad S; Abdul Ghani S; Hemalata Rajagopal T
J Curr Glaucoma Pract 2013[May]; 7 (2): 49-53 PMID26997782show ga
Glaucoma is now regarded as a neurodegenerative disorder. A number of theories including the mechanical and vascular models have been used to explain the pathogenesis of glaucoma. However, there is now increasing evidence of biochemical molecules which may play a part in it's causation. These biochemical mechanisms include the role of excitatory aminoacids, caspases, protein kinases, oxygen free radicals, nitric oxide, TNF-alpha, neurotrophins and metalloproteins. This paper reviews these new developments which form the biochemical basis of glaucomatous neural degeneration.How to cite this article: Ahmad SS, Ghani SA, Rajagopal TH. Current Concepts in the Biochemical Mechanisms of Glaucomatous Neurodegeneration. J Current Glau Prac 2013;7(2):49-53.