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10.1038/ncomms10464 http://scihub22266oqcxt.onion/10.1038/ncomms10464 C4740880!4740880!26833085     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26833085|t=2016. Joint mouse?human phenome-wide association to test gene function and disease risk |pdf=|usr=}}{{26833085}} gab.com Text Joint mouse human phenome-wide association to test gene function and disease risk JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26833085 #FOAvip Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ?5 million sequence variants, and we compare our results to those extracted from a matched analysis of gene variants in a large human cohort. For the mouse cohort, we amassed a deep and broad open-access phenome consisting of ?4,500 metabolic, physiological, pharmacological and behavioural traits, and more than 90 independent expression quantitative trait locus (QTL), transcriptome, proteome, metagenome and metabolome data sets?by far the largest coherent phenome for any experimental cohort (www.genenetwork.org). We tested downstream effects of subsets of variants and discovered several novel associations, including a missense mutation in fumarate hydratase that controls variation in the mitochondrial unfolded protein response in both mouse and Caenorhabditis elegans, and missense mutations in Col6a5 that underlies variation in bone mineral density in both mouse and human. Twit Text FOAVip Joint mouse human phenome-wide association to test gene function and disease risk ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26833085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26833085 #FOAvip English Wikipedia <ref>{{Cite pmid|26833085}}</ref> Joint mouse?human phenome-wide association to test gene function and disease risk #MMPMID26833085 Wang X; Pandey AK; Mulligan MK; Williams EG; Mozhui K; Li Z; Jovaisaite V; Quarles LD; Xiao Z; Huang J; Capra JA; Chen Z; Taylor WL; Bastarache L; Niu X; Pollard KS; Ciobanu DC; Reznik AO; Tishkov AV; Zhulin IB; Peng J; Nelson SF; Denny JC; Auwerx J; Lu L; Williams RW Nat Commun 2016[]; 7 (ä): ä PMID26833085show ga Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ?5 million sequence variants, and we compare our results to those extracted from a matched analysis of gene variants in a large human cohort. For the mouse cohort, we amassed a deep and broad open-access phenome consisting of ?4,500 metabolic, physiological, pharmacological and behavioural traits, and more than 90 independent expression quantitative trait locus (QTL), transcriptome, proteome, metagenome and metabolome data sets?by far the largest coherent phenome for any experimental cohort (www.genenetwork.org). We tested downstream effects of subsets of variants and discovered several novel associations, including a missense mutation in fumarate hydratase that controls variation in the mitochondrial unfolded protein response in both mouse and Caenorhabditis elegans, and missense mutations in Col6a5 that underlies variation in bone mineral density in both mouse and human. äJoint mouse?human phenome-wide association to test gene function and d(epmc).pdf DeepDyve Pubget Overpricing