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10.1038/ncomms10202 http://scihub22266oqcxt.onion/10.1038/ncomms10202 C4740752!4740752 !26831565     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26831565 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10202 Nephropedia Template TP {{tp|p=26831565 |t=2016. Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA |pdf=|usr=}}{{26831565 }} gab.com Text Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26831565 #FOAvip Recently, we showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the viral DNA. The mechanism by which this occurs has heretofore been unknown. We show sliding of these proteins along DNA occurs on a new vehicle in molecular biology, a 'molecular sled' named pVIc. This 11-amino acid viral peptide binds to DNA independent of sequence. pVIc slides on DNA, exhibiting the fastest one-dimensional diffusion constant, 26±1.8 × 10(6) (bp)(2)?s(-1). pVIc is a 'molecular sled,' because it can slide heterologous cargos along DNA, for example, a streptavidin tetramer. Similar peptides, for example, from the C terminus of ?-actin or NLSIII of the p53 protein, slide along DNA. Characteristics of the 'molecular sled' in its milieu (virion, nucleus) have implications for how proteins in the nucleus of cells interact and imply a new form of biochemistry, one-dimensional biochemistry. Twit Text FOAVip Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26831565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26831565 #FOAvip English Wikipedia <ref>{{Cite pmid|26831565 }}</ref> Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA #MMPMID26831565 Mangel WF ; McGrath WJ ; Xiong K ; Graziano V ; Blainey PC Nat Commun 2016[Feb]; 7 (ä): 10202 PMID26831565 show ga Recently, we showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the viral DNA. The mechanism by which this occurs has heretofore been unknown. We show sliding of these proteins along DNA occurs on a new vehicle in molecular biology, a 'molecular sled' named pVIc. This 11-amino acid viral peptide binds to DNA independent of sequence. pVIc slides on DNA, exhibiting the fastest one-dimensional diffusion constant, 26±1.8 × 10(6) (bp)(2)?s(-1). pVIc is a 'molecular sled,' because it can slide heterologous cargos along DNA, for example, a streptavidin tetramer. Similar peptides, for example, from the C terminus of ?-actin or NLSIII of the p53 protein, slide along DNA. Characteristics of the 'molecular sled' in its milieu (virion, nucleus) have implications for how proteins in the nucleus of cells interact and imply a new form of biochemistry, one-dimensional biochemistry. |Adenoviruses, Human/genetics/*physiology [MESH] |Amino Acid Sequence [MESH] |Capsid Proteins/chemistry/genetics/metabolism [MESH] |Cysteine Endopeptidases/chemistry/genetics/*metabolism [MESH] |DNA, Viral/*chemistry/genetics/metabolism [MESH] |Gene Expression Regulation, Enzymologic/physiology [MESH] |Gene Expression Regulation, Viral/*physiology [MESH] |Models, Molecular [MESH] |Peptides/*chemistry [MESH] |Protein Binding [MESH]Molecular sled is an eleven-amino acid vehicle facilitating biochemica(epmc).pdf DeepDyve Pubget Overpricing