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10.1136/annrheumdis-2015-207704 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2015-207704 C4740245!4740245 !26238146     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26238146 &cmd=llinks): Failed to open stream: HTTP request failed! 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Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses Health Study II |pdf=|usr=}}{{26238146 }} gab.com Text Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses Health Study II JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26238146 #FOAvip OBJECTIVES: The aetiologies of endometriosis, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are all characterised by immune dysfunction. SLE and RA occur more often in women, and reproductive and hormonal factors have been shown to be related to increased risk. However, only one previous study has evaluated the temporal association between endometriosis and SLE or RA. We sought to investigate the association between laparoscopically confirmed endometriosis and subsequently diagnosed SLE and RA. METHODS: We analysed data from the Nurses' Health Study II (n=114?453 women) over a 22-year follow-up period. Multivariable, time-varying Cox proportional hazards models were used to calculate HRs and 95% CIs for the association between laparoscopically confirmed endometriosis and confirmed incident SLE or RA. RESULTS: From 1989 to 2011, 103 incident cases of SLE and 390 cases of RA were confirmed. Laparoscopically confirmed endometriosis was significantly associated with subsequent SLE diagnosis (HR=2.03; CI 1.17 to 3.51) and RA diagnosis (HR=1.41; CI 1.05 to 1.89). These associations were robust to adjustment for SLE or RA risk factors and for potential confounders; however, adjustment for hysterectomy and oophorectomy attenuated both relations such that they were no longer significant. No significant differences by infertility status or age (<45?years) were observed. CONCLUSIONS: Our findings suggest an association between endometriosis and risk of SLE and RA. It remains to be understood whether and how endometriosis itself, or hysterectomy or other factors associated with endometriosis, is related to risk of SLE or RA. Twit Text FOAVip Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses Health Study II ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26238146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26238146 #FOAvip English Wikipedia <ref>{{Cite pmid|26238146 }}</ref> Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses Health Study II #MMPMID26238146 Harris HR ; Costenbader KH ; Mu F ; Kvaskoff M ; Malspeis S ; Karlson EW ; Missmer SA Ann Rheum Dis 2016[Jul]; 75 (7 ): 1279-84 PMID26238146 show ga OBJECTIVES: The aetiologies of endometriosis, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are all characterised by immune dysfunction. SLE and RA occur more often in women, and reproductive and hormonal factors have been shown to be related to increased risk. However, only one previous study has evaluated the temporal association between endometriosis and SLE or RA. We sought to investigate the association between laparoscopically confirmed endometriosis and subsequently diagnosed SLE and RA. METHODS: We analysed data from the Nurses' Health Study II (n=114?453 women) over a 22-year follow-up period. Multivariable, time-varying Cox proportional hazards models were used to calculate HRs and 95% CIs for the association between laparoscopically confirmed endometriosis and confirmed incident SLE or RA. RESULTS: From 1989 to 2011, 103 incident cases of SLE and 390 cases of RA were confirmed. Laparoscopically confirmed endometriosis was significantly associated with subsequent SLE diagnosis (HR=2.03; CI 1.17 to 3.51) and RA diagnosis (HR=1.41; CI 1.05 to 1.89). These associations were robust to adjustment for SLE or RA risk factors and for potential confounders; however, adjustment for hysterectomy and oophorectomy attenuated both relations such that they were no longer significant. No significant differences by infertility status or age (<45?years) were observed. CONCLUSIONS: Our findings suggest an association between endometriosis and risk of SLE and RA. It remains to be understood whether and how endometriosis itself, or hysterectomy or other factors associated with endometriosis, is related to risk of SLE or RA. |Adult [MESH] |Arthritis, Rheumatoid/*etiology [MESH] |Endometriosis/*complications [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/*etiology [MESH] |Nurses/statistics & numerical data [MESH] |Proportional Hazards Models [MESH] |Prospective Studies [MESH]Endometriosis and the risks of systemic lupus erythematosus and rheuma(epmc).pdf DeepDyve Pubget Overpricing