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10.1038/ncomms10503 http://scihub22266oqcxt.onion/10.1038/ncomms10503 C4738365!4738365!26818705     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26818705|t=2016. Serotonin neurons in the dorsal raphe nucleus encode reward signals |pdf=|usr=}}{{26818705}} gab.com Text Serotonin neurons in the dorsal raphe nucleus encode reward signals JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26818705 #FOAvip The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including sucrose, food, sex and social interaction rapidly activate 5-HT neurons, but aversive stimuli including quinine and footshock do not. Both expected and unexpected rewards activate 5-HT neurons. After mice learn to wait for sucrose delivery, most 5-HT neurons fire tonically during waiting and then phasically on reward acquisition. Finally, GABA neurons are activated by aversive stimuli but inhibited when mice seek rewards. Thus, DRN 5-HT neurons positively encode a wide range of reward signals during anticipatory and consummatory phases of reward responses. Moreover, GABA neurons play a complementary role in reward processing. Twit Text FOAVip Serotonin neurons in the dorsal raphe nucleus encode reward signals ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26818705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26818705 #FOAvip English Wikipedia <ref>{{Cite pmid|26818705}}</ref> Serotonin neurons in the dorsal raphe nucleus encode reward signals #MMPMID26818705 Li Y; Zhong W; Wang D; Feng Q; Liu Z; Zhou J; Jia C; Hu F; Zeng J; Guo Q; Fu L; Luo M Nat Commun 2016[]; 7 (ä): ä PMID26818705show ga The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including sucrose, food, sex and social interaction rapidly activate 5-HT neurons, but aversive stimuli including quinine and footshock do not. Both expected and unexpected rewards activate 5-HT neurons. After mice learn to wait for sucrose delivery, most 5-HT neurons fire tonically during waiting and then phasically on reward acquisition. Finally, GABA neurons are activated by aversive stimuli but inhibited when mice seek rewards. Thus, DRN 5-HT neurons positively encode a wide range of reward signals during anticipatory and consummatory phases of reward responses. Moreover, GABA neurons play a complementary role in reward processing. äSerotonin neurons in the dorsal raphe nucleus encode reward signals (epmc).pdf DeepDyve Pubget Overpricing