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10.1038/ncomms10393 http://scihub22266oqcxt.onion/10.1038/ncomms10393 C4737732!4737732!26804021     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26804021|t=2016. Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing |pdf=|usr=}}{{26804021}} gab.com Text Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26804021 #FOAvip A chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure. Here we report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe. We show that Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body ?knob'. Furthermore, the absence of Sgo2 leads to the derepression of the subtelomeric genes and premature DNA replication at the subtelomeric late origins. Thus, the subtelomeric specialized chromatin domain organized by Sgo2 represses both transcription and replication to ensure proper gene expression and replication timing. Twit Text FOAVip Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26804021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26804021 #FOAvip English Wikipedia <ref>{{Cite pmid|26804021}}</ref> Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing #MMPMID26804021 Tashiro S; Handa T; Matsuda A; Ban T; Takigawa T; Miyasato K; Ishii K; Kugou K; Ohta K; Hiraoka Y; Masukata H; Kanoh J Nat Commun 2016[]; 7 (ä): ä PMID26804021show ga A chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure. Here we report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe. We show that Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body ?knob'. Furthermore, the absence of Sgo2 leads to the derepression of the subtelomeric genes and premature DNA replication at the subtelomeric late origins. Thus, the subtelomeric specialized chromatin domain organized by Sgo2 represses both transcription and replication to ensure proper gene expression and replication timing. äShugoshin forms a specialized chromatin domain at subtelomeres that re(epmc).pdf DeepDyve Pubget Overpricing