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10.1038/ncomms10330 http://scihub22266oqcxt.onion/10.1038/ncomms10330 C4735759!4735759!26787103     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26787103|t=2016. Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2 |pdf=|usr=}}{{26787103}} gab.com Text Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26787103 #FOAvip In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions, which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid (PBA), a chemical chaperone already used in humans, as a novel therapeutic strategy capable to counteract the toxic effect of proteinuria. Mechanistically, we show that albumin induces tubular unfolded protein response via cytosolic calcium rise, which leads to tubular apoptosis by Lipocalin 2 (LCN2) modulation through ATF4. Consistent with the key role of LCN2 in CKD progression, Lcn2 gene inactivation decreases ER stress-induced apoptosis, tubulointerstitial lesions and mortality in proteinuric mice. More importantly, the inhibition of this pathway by PBA protects kidneys from morphological and functional degradation in proteinuric mice. These results are relevant to human CKD, as LCN2 is increased in proteinuric patients. In conclusion, our study identifies a therapeutic strategy susceptible to improve the benefit of RAS inhibitors in proteinuria-induced CKD progression. Twit Text FOAVip Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26787103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26787103 #FOAvip English Wikipedia <ref>{{Cite pmid|26787103}}</ref> Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2 #MMPMID26787103 El Karoui K; Viau A; Dellis O; Bagattin A; Nguyen C; Baron W; Burtin M; Broueilh M; Heidet L; Mollet G; Druilhe A; Antignac C; Knebelmann B; Friedlander G; Bienaimé F; Gallazzini M; Terzi F Nat Commun 2016[]; 7 (ä): ä PMID26787103show ga In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions, which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid (PBA), a chemical chaperone already used in humans, as a novel therapeutic strategy capable to counteract the toxic effect of proteinuria. Mechanistically, we show that albumin induces tubular unfolded protein response via cytosolic calcium rise, which leads to tubular apoptosis by Lipocalin 2 (LCN2) modulation through ATF4. Consistent with the key role of LCN2 in CKD progression, Lcn2 gene inactivation decreases ER stress-induced apoptosis, tubulointerstitial lesions and mortality in proteinuric mice. More importantly, the inhibition of this pathway by PBA protects kidneys from morphological and functional degradation in proteinuric mice. These results are relevant to human CKD, as LCN2 is increased in proteinuric patients. In conclusion, our study identifies a therapeutic strategy susceptible to improve the benefit of RAS inhibitors in proteinuria-induced CKD progression. äEndoplasmic reticulum stress drives proteinuria-induced kidney lesions(epmc).pdf DeepDyve Pubget Overpricing