Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function #MMPMID26831199
Pattaro C; Teumer A; Gorski M; Chu AY; Li M; Mijatovic V; Garnaas M; Tin A; Sorice R; Li Y; Taliun D; Olden M; Foster M; Yang Q; Chen MH; Pers TH; Johnson AD; Ko YA; Fuchsberger C; Tayo B; Nalls M; Feitosa MF; Isaacs A; Dehghan A; d'Adamo P; Adeyemo A; Dieffenbach AK; Zonderman AB; Nolte IM; van der Most PJ; Wright AF; Shuldiner AR; Morrison AC; Hofman A; Smith AV; Dreisbach AW; Franke A; Uitterlinden AG; Metspalu A; Tonjes A; Lupo A; Robino A; Johansson Å; Demirkan A; Kollerits B; Freedman BI; Ponte B; Oostra BA; Paulweber B; Krämer BK; Mitchell BD; Buckley BM; Peralta CA; Hayward C; Helmer C; Rotimi CN; Shaffer CM; Müller C; Sala C; van Duijn CM; Saint-Pierre A; Ackermann D; Shriner D; Ruggiero D; Toniolo D; Lu Y; Cusi D; Czamara D; Ellinghaus D; Siscovick DS; Ruderfer D; Gieger C; Grallert H; Rochtchina E; Atkinson EJ; Holliday EG; Boerwinkle E; Salvi E; Bottinger EP; Murgia F; Rivadeneira F; Ernst F; Kronenberg F; Hu FB; Navis GJ; Curhan GC; Ehret GB; Homuth G; Coassin S; Thun GA; Pistis G; Gambaro G; Malerba G; Montgomery GW; Eiriksdottir G; Jacobs G; Li G; Wichmann HE; Campbell H; Schmidt H; Wallaschofski H; Völzke H; Brenner H; Kroemer HK; Kramer H; Lin H; Leach IM; Ford I; Guessous I; Rudan I; Prokopenko I; Borecki I; Heid IM; Kolcic I; Persico I; Jukema JW; Wilson JF; Felix JF; Divers J; Lambert JC; Stafford JM; Gaspoz JM; Smith JA; Faul JD; Wang JJ; Ding J; Hirschhorn JN; Attia J; Whitfield JB; Chalmers J; Viikari J; Coresh J; Denny JC; Karjalainen J; Fernandes JK; Endlich K; Butterbach K; Keene KL; Lohman K; Portas L; Launer LJ; Lyytikäinen LP; Yengo L; Franke L; Ferrucci L; Rose LM; Kedenko L; Rao M; Struchalin M; Kleber ME; Cavalieri M; Haun M; Cornelis MC; Ciullo M; Pirastu M; de Andrade M; McEvoy MA; Woodward M; Adam M; Cocca M; Nauck M; Imboden M; Waldenberger M; Pruijm M; Metzger M; Stumvoll M; Evans MK; Sale MM; Kähönen M; Boban M; Bochud M; Rheinberger M; Verweij N; Bouatia-Naji N; Martin NG; Hastie N; Probst-Hensch N; Soranzo N; Devuyst O; Raitakari O; Gottesman O; Franco OH; Polasek O; Gasparini P; Munroe PB; Ridker PM; Mitchell P; Muntner P; Meisinger C; Smit JH; Kovacs P; Wild PS; Froguel P; Rettig R; Mägi R; Biffar R; Schmidt R; Middelberg RPS; Carroll RJ; Penninx BW; Scott RJ; Katz R; Sedaghat S; Wild SH; Kardia SLR; Ulivi S; Hwang SJ; Enroth S; Kloiber S; Trompet S; Stengel B; Hancock SJ; Turner ST; Rosas SE; Stracke S; Harris TB; Zeller T; Zemunik T; Lehtimäki T; Illig T; Aspelund T; Nikopensius T; Esko T; Tanaka T; Gyllensten U; Völker U; Emilsson V; Vitart V; Aalto V; Gudnason V; Chouraki V; Chen WM; Igl W; März W; Koenig W; Lieb W; Loos RJF; Liu Y; Snieder H; Pramstaller PP; Parsa A; O'Connell JR; Susztak K; Hamet P; Tremblay J; de Boer IH; Böger CA; Goessling W; Chasman DI; Köttgen A; Kao WHL; Fox CS
Nat Commun 2016[]; 7 (ä): ä PMID26831199show ga
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
free
free
free
Nat+Commun 2016 ; 7 (ä): ä
