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10.1038/ncomms10347 http://scihub22266oqcxt.onion/10.1038/ncomms10347 C4735525!4735525!26757928     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26757928|t=2016. Methylation-dependent regulation of HIF-1? stability restricts retinal and tumour angiogenesis |pdf=|usr=}}{{26757928}} gab.com Text Methylation-dependent regulation of HIF-1 stability restricts retinal and tumour angiogenesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26757928 #FOAvip Hypoxia-inducible factor-1? (HIF-1?) mediates hypoxic responses and regulates gene expression involved in angiogenesis, invasion and metabolism. Among the various HIF-1? posttranslational modifications, HIF-1? methylation and its physiological role have not yet been elucidated. Here we show that HIF-1? is methylated by SET7/9 methyltransferase, and that lysine-specific demethylase 1 reverses its methylation. The functional consequence of HIF-1? methylation is the modulation of HIF-1? stability primarily in the nucleus, independent of its proline hydroxylation, during long-term hypoxic and normoxic conditions. Knock-in mice bearing a methylation-defective Hif1aKA/KA allele exhibit enhanced retinal angiogenesis and tumour vascularization via HIF-1? stabilization. Importantly, S28Y and R30Q mutations of HIF-1?, found in human cancers, are involved in the altered HIF-1? stability. Together, these results demonstrate a role for HIF-1? methylation in regulating protein stability, thereby modulating biological output including retinal and tumour angiogenesis, with therapeutic implications in human cancer. Twit Text FOAVip Methylation-dependent regulation of HIF-1 stability restricts retinal and tumour angiogenesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26757928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26757928 #FOAvip English Wikipedia <ref>{{Cite pmid|26757928}}</ref> Methylation-dependent regulation of HIF-1? stability restricts retinal and tumour angiogenesis #MMPMID26757928 Kim Y; Nam HJ; Lee J; Park DY; Kim C; Yu YS; Kim D; Park SW; Bhin J; Hwang D; Lee H; Koh GY; Baek SH Nat Commun 2016[]; 7 (ä): ä PMID26757928show ga Hypoxia-inducible factor-1? (HIF-1?) mediates hypoxic responses and regulates gene expression involved in angiogenesis, invasion and metabolism. Among the various HIF-1? posttranslational modifications, HIF-1? methylation and its physiological role have not yet been elucidated. Here we show that HIF-1? is methylated by SET7/9 methyltransferase, and that lysine-specific demethylase 1 reverses its methylation. The functional consequence of HIF-1? methylation is the modulation of HIF-1? stability primarily in the nucleus, independent of its proline hydroxylation, during long-term hypoxic and normoxic conditions. Knock-in mice bearing a methylation-defective Hif1aKA/KA allele exhibit enhanced retinal angiogenesis and tumour vascularization via HIF-1? stabilization. Importantly, S28Y and R30Q mutations of HIF-1?, found in human cancers, are involved in the altered HIF-1? stability. Together, these results demonstrate a role for HIF-1? methylation in regulating protein stability, thereby modulating biological output including retinal and tumour angiogenesis, with therapeutic implications in human cancer. äMethylation-dependent regulation of HIF-1? stability restricts retinal(epmc).pdf DeepDyve Pubget Overpricing