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10.1093/toxsci/kfv113 http://scihub22266oqcxt.onion/10.1093/toxsci/kfv113 C4734116!4734116!26048654     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Sci 2015 ; 147 (1): 127-39 Nephropedia Template TP {{tp|p=26048654|t=2015. Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses |pdf=|usr=}}{{26048654}} gab.com Text Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses JO: Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26048654 #FOAvip Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses. Triclosan (0%?3%) was applied topically at 24-h intervals to the ear pinnae of OVA-sensitized BALB/c mice. Skin and draining lymph nodes were evaluated for cellular responses and cytokine expression over time. The effects of triclosan (0%?0.75%) on cytokine expression in a human skin tissue model were also examined. Exposure to triclosan increased the expression of TSLP, IL-1?, and TNF-? in the skin with concomitant decreases in IL-25, IL-33, and IL-1?. Similar changes in TSLP, IL1B, and IL33 expression occurred in human skin. Topical application of triclosan also increased draining lymph node cellularity consisting of activated CD86+GL-7+ B cells, CD80+CD86+ dendritic cells, GATA-3+OX-40+IL-4+IL-13+ Th2 cells and IL-17 A+ CD4 T cells. In vivo antibody blockade of TSLP reduced skin irritation, IL-1? expression, lymph node cellularity, and Th2 responses augmented by triclosan. Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. Twit Text FOAVip Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses ????Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26048654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26048654 #FOAvip English Wikipedia <ref>{{Cite pmid|26048654}}</ref> Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses #MMPMID26048654 Marshall NB; Lukomska E; Long CM; Kashon ML; Sharpnack DD; Nayak AP; Anderson KL; Meade BJ; Anderson SE Toxicol Sci 2015[Sep]; 147 (1): 127-39 PMID26048654show ga Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses. Triclosan (0%?3%) was applied topically at 24-h intervals to the ear pinnae of OVA-sensitized BALB/c mice. Skin and draining lymph nodes were evaluated for cellular responses and cytokine expression over time. The effects of triclosan (0%?0.75%) on cytokine expression in a human skin tissue model were also examined. Exposure to triclosan increased the expression of TSLP, IL-1?, and TNF-? in the skin with concomitant decreases in IL-25, IL-33, and IL-1?. Similar changes in TSLP, IL1B, and IL33 expression occurred in human skin. Topical application of triclosan also increased draining lymph node cellularity consisting of activated CD86+GL-7+ B cells, CD80+CD86+ dendritic cells, GATA-3+OX-40+IL-4+IL-13+ Th2 cells and IL-17 A+ CD4 T cells. In vivo antibody blockade of TSLP reduced skin irritation, IL-1? expression, lymph node cellularity, and Th2 responses augmented by triclosan. Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. äTriclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 A(epmc).pdf DeepDyve Pubget Overpricing