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10.1016/j.semnephrol.2015.02.005 http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2015.02.005 C4731878!4731878!25966347     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25966347&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Nephrol 2015 ; 35 (2): 156-67 Nephropedia Template TP {{tp|p=25966347|t=2015. Endothelin and the Glomerulus in Chronic Kidney Disease |pdf=|usr=}}{{25966347}} gab.com Text Endothelin and the Glomerulus in Chronic Kidney Disease JO: Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25966347 #FOAvip Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is constitutively expressed in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function. Under disease conditions, increases in ET-1 are critically involved in initiating and maintaining glomerular inflammation, glomerular basement membrane hypertrophy, and injury of podocytes (visceral epithelial cells), thereby promoting proteinuria and glomerulosclerosis. Here, we review the role of ET-1 in the function of glomerular endothelial cells, visceral (podocytes) and parietal epithelial cells, mesangial cells, the glomerular basement membrane, stromal cells, inflammatory cells, and mesenchymal stem cells. We also discuss molecular mechanisms by which ET-1 ? predominantly through activation of the ETA receptor - contributes to injury to glomerular cells and review preclinical and clinical evidence supporting its pathogenic role in glomerular injury in chronic renal disease. Finally, the therapeutic rationale for endothelin antagonists as a new class of antiproteinuric drugs is discussed. Twit Text FOAVip Endothelin and the Glomerulus in Chronic Kidney Disease ????Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25966347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25966347 #FOAvip English Wikipedia <ref>{{Cite pmid|25966347}}</ref> Endothelin and the Glomerulus in Chronic Kidney Disease #MMPMID25966347 Barton M; Sorokin A Semin Nephrol 2015[Mar]; 35 (2): 156-67 PMID25966347show ga Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is constitutively expressed in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function. Under disease conditions, increases in ET-1 are critically involved in initiating and maintaining glomerular inflammation, glomerular basement membrane hypertrophy, and injury of podocytes (visceral epithelial cells), thereby promoting proteinuria and glomerulosclerosis. Here, we review the role of ET-1 in the function of glomerular endothelial cells, visceral (podocytes) and parietal epithelial cells, mesangial cells, the glomerular basement membrane, stromal cells, inflammatory cells, and mesenchymal stem cells. We also discuss molecular mechanisms by which ET-1 ? predominantly through activation of the ETA receptor - contributes to injury to glomerular cells and review preclinical and clinical evidence supporting its pathogenic role in glomerular injury in chronic renal disease. Finally, the therapeutic rationale for endothelin antagonists as a new class of antiproteinuric drugs is discussed. äEndothelin and the Glomerulus in Chronic Kidney Disease (epmc).pdf DeepDyve Pubget Overpricing