Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/labinvest.2015.144 http://scihub22266oqcxt.onion/10.1038/labinvest.2015.144 C4731283!4731283 !26618721     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26618721 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26618721 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Lab+Invest 2016 ; 96 (2 ): 116-36 Nephropedia Template TP {{tp|p=26618721 |t=2016. The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies |pdf=|usr=}}{{26618721 }} gab.com Text The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=26618721 #FOAvip The canonical WNT/?-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of ?-catenin-mediated transcriptional activity. Canonical WNTs control the ?-catenin dynamics as the cytoplasmic level of ?-catenin is tightly regulated via phosphorylation by the 'destruction complex', consisting of glycogen synthase kinase 3? (GSK3?), casein kinase 1? (CK1?), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/?-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. Twit Text FOAVip The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=26618721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26618721 #FOAvip English Wikipedia <ref>{{Cite pmid|26618721 }}</ref> The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies #MMPMID26618721 Yang K ; Wang X ; Zhang H ; Wang Z ; Nan G ; Li Y ; Zhang F ; Mohammed MK ; Haydon RC ; Luu HH ; Bi Y ; He TC Lab Invest 2016[Feb]; 96 (2 ): 116-36 PMID26618721 show ga The canonical WNT/?-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of ?-catenin-mediated transcriptional activity. Canonical WNTs control the ?-catenin dynamics as the cytoplasmic level of ?-catenin is tightly regulated via phosphorylation by the 'destruction complex', consisting of glycogen synthase kinase 3? (GSK3?), casein kinase 1? (CK1?), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/?-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. |*Carcinogenesis [MESH] |*Stem Cells [MESH] |*Wnt Proteins [MESH] |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Drug Discovery [MESH] |Humans [MESH] |Mice [MESH]The evolving roles of canonical WNT signaling in stem cells and tumori(epmc).pdf DeepDyve Pubget Overpricing