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10.1038/nn.4196 http://scihub22266oqcxt.onion/10.1038/nn.4196 C4731241!4731241!26691829     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2016 ; 19 (2): 308-15 Nephropedia Template TP {{tp|p=26691829|t=2016. Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs |pdf=|usr=}}{{26691829}} gab.com Text Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26691829 #FOAvip Understanding the functions of a brain region requires knowing the neural representations of its myriad inputs, local neurons, and outputs. Primary visual cortex (V1) has long been thought to compute visual orientation from untuned thalamic inputs, but very few thalamic inputs have been measured in any mammal. We determined the response properties of ~28,000 thalamic boutons and ~4,000 cortical neurons in layers 1?5 of awake mouse V1. With adaptive optics allowing accurate measurement of bouton activity deep in cortex, we found that around half of the boutons in the main thalamorecipient L4 carry orientation-tuned information, and their orientation/direction biases are also dominant in the L4 neuron population, suggesting that these neurons may inherit their selectivity from tuned thalamic inputs. Cortical neurons in all layers exhibited sharper tuning than thalamic boutons and a greater diversity of preferred orientations. Our results provide data-rich constraints for refining mechanistic models of cortical computation. Twit Text FOAVip Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26691829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26691829 #FOAvip English Wikipedia <ref>{{Cite pmid|26691829}}</ref> Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs #MMPMID26691829 Sun W; Tan Z; Mensh BD; Ji N Nat Neurosci 2016[Feb]; 19 (2): 308-15 PMID26691829show ga Understanding the functions of a brain region requires knowing the neural representations of its myriad inputs, local neurons, and outputs. Primary visual cortex (V1) has long been thought to compute visual orientation from untuned thalamic inputs, but very few thalamic inputs have been measured in any mammal. We determined the response properties of ~28,000 thalamic boutons and ~4,000 cortical neurons in layers 1?5 of awake mouse V1. With adaptive optics allowing accurate measurement of bouton activity deep in cortex, we found that around half of the boutons in the main thalamorecipient L4 carry orientation-tuned information, and their orientation/direction biases are also dominant in the L4 neuron population, suggesting that these neurons may inherit their selectivity from tuned thalamic inputs. Cortical neurons in all layers exhibited sharper tuning than thalamic boutons and a greater diversity of preferred orientations. Our results provide data-rich constraints for refining mechanistic models of cortical computation. äThalamus provides layer 4 of primary visual cortex with orientation- a(epmc).pdf DeepDyve Pubget Overpricing