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10.1038/ncomms10230 http://scihub22266oqcxt.onion/10.1038/ncomms10230 C4729927!4729927!26756352     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26756352|t=2016. Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity |pdf=|usr=}}{{26756352}} gab.com Text Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26756352 #FOAvip Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer. Twit Text FOAVip Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26756352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26756352 #FOAvip English Wikipedia <ref>{{Cite pmid|26756352}}</ref> Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity #MMPMID26756352 Laurent V; Guérard A; Mazerolles C; Le Gonidec S; Toulet A; Nieto L; Zaidi F; Majed B; Garandeau D; Socrier Y; Golzio M; Cadoudal T; Chaoui K; Dray C; Monsarrat B; Schiltz O; Wang YY; Couderc B; Valet P; Malavaud B; Muller C Nat Commun 2016[]; 7 (ä): ä PMID26756352show ga Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer. äPeriprostatic adipocytes act as a driving force for prostate cancer pr(epmc).pdf DeepDyve Pubget Overpricing