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10.1038/ncomms10087 http://scihub22266oqcxt.onion/10.1038/ncomms10087 C4729925!4729925 !26753883     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26753883 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10087 Nephropedia Template TP {{tp|p=26753883 |t=2016. Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |pdf=|usr=}}{{26753883 }} gab.com Text Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26753883 #FOAvip Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of peripheral ALCL pathogenesis where the malignancy is initiated in early thymocytes, before T-cell receptor (TCR) ?-rearrangement, which is bypassed in CD4/NPM-ALK transgenic mice following Notch1 expression. However, we find that a TCR is required for thymic egress and development of peripheral murine tumours, yet this TCR must be downregulated for T-cell lymphomagenesis. In keeping with this, clonal TCR rearrangements in human ALCL are predominantly in-frame, but often aberrant, with clonal TCR? but no comparable clonal TCR? rearrangement, yielding events that would not normally be permissive for survival during thymic development. Children affected by ALCL may thus harbour thymic lymphoma-initiating cells capable of seeding relapse after chemotherapy. Twit Text FOAVip Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26753883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26753883 #FOAvip English Wikipedia <ref>{{Cite pmid|26753883 }}</ref> Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress #MMPMID26753883 Malcolm TI ; Villarese P ; Fairbairn CJ ; Lamant L ; Trinquand A ; Hook CE ; Burke GA ; Brugières L ; Hughes K ; Payet D ; Merkel O ; Schiefer AI ; Ashankyty I ; Mian S ; Wasik M ; Turner M ; Kenner L ; Asnafi V ; Macintyre E ; Turner SD Nat Commun 2016[Jan]; 7 (ä): 10087 PMID26753883 show ga Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of peripheral ALCL pathogenesis where the malignancy is initiated in early thymocytes, before T-cell receptor (TCR) ?-rearrangement, which is bypassed in CD4/NPM-ALK transgenic mice following Notch1 expression. However, we find that a TCR is required for thymic egress and development of peripheral murine tumours, yet this TCR must be downregulated for T-cell lymphomagenesis. In keeping with this, clonal TCR rearrangements in human ALCL are predominantly in-frame, but often aberrant, with clonal TCR? but no comparable clonal TCR? rearrangement, yielding events that would not normally be permissive for survival during thymic development. Children affected by ALCL may thus harbour thymic lymphoma-initiating cells capable of seeding relapse after chemotherapy. |*Genes, T-Cell Receptor alpha [MESH] |*Genes, T-Cell Receptor beta [MESH] |Adult [MESH] |Animals [MESH] |CD4 Antigens/metabolism [MESH] |Cell Line, Tumor [MESH] |Child [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Flow Cytometry [MESH] |Gene Rearrangement, T-Lymphocyte [MESH] |Genes, RAG-1/genetics [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Jurkat Cells [MESH] |Lymphoma, Large-Cell, Anaplastic/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Protein-Tyrosine Kinases/metabolism [MESH] |Receptor, Notch1/metabolism [MESH] |Receptors, Antigen, T-Cell, alpha-beta/genetics/*metabolism [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Thymocytes/*metabolism [MESH]Anaplastic large cell lymphoma arises in thymocytes and requires trans(epmc).pdf DeepDyve Pubget Overpricing