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10.1146/annurev-genom-090413-025437 http://scihub22266oqcxt.onion/10.1146/annurev-genom-090413-025437 C4729449!4729449!26077819     free     free     free       Annu+Rev+Genomics+Hum+Genet 2015 ; 16 (ä): 55-77 Nephropedia Template TP {{tp|p=26077819|t=2015. Non-CG Methylation in the Human Genome |pdf=|usr=}}{{26077819}} gab.com Text Non-CG Methylation in the Human Genome JO: Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=26077819 #FOAvip DNA methylation is a chemical modification that occurs predominantly on CG dinucleotides in mammalian genomes. However, recent studies have revealed that non-CG methylation (mCH) is abundant and nonrandomly distributed in the genomes of pluripotent cells and brain cells, and is present at lower levels in many other human cells and tissues. Surprisingly, mCH in pluripotent cells is distinct from that in brain cells in terms of sequence specificity and association with transcription, indicating the existence of different mCH pathways. In addition, several recent studies have begun to reveal the biological significance of mCH in diverse cellular processes. In reprogrammed somatic cells, mCH marks megabase-scale regions that have failed to revert to the pluripotent epigenetic state. In myocytes, promoter mCH accumulation is associated with the transcriptional response to environmental factors. In brain cells, mCH accumulates during the establishment of neural circuits and is associated with Rett syndrome. In this review, we summarize the current understanding of mCH and its possible functional consequences in different biological contexts. Twit Text FOAVip Non-CG Methylation in the Human Genome ????Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=26077819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26077819 #FOAvip English Wikipedia <ref>{{Cite pmid|26077819}}</ref> Non-CG Methylation in the Human Genome #MMPMID26077819 He Y; Ecker JR Annu Rev Genomics Hum Genet 2015[]; 16 (ä): 55-77 PMID26077819show ga DNA methylation is a chemical modification that occurs predominantly on CG dinucleotides in mammalian genomes. However, recent studies have revealed that non-CG methylation (mCH) is abundant and nonrandomly distributed in the genomes of pluripotent cells and brain cells, and is present at lower levels in many other human cells and tissues. Surprisingly, mCH in pluripotent cells is distinct from that in brain cells in terms of sequence specificity and association with transcription, indicating the existence of different mCH pathways. In addition, several recent studies have begun to reveal the biological significance of mCH in diverse cellular processes. In reprogrammed somatic cells, mCH marks megabase-scale regions that have failed to revert to the pluripotent epigenetic state. In myocytes, promoter mCH accumulation is associated with the transcriptional response to environmental factors. In brain cells, mCH accumulates during the establishment of neural circuits and is associated with Rett syndrome. In this review, we summarize the current understanding of mCH and its possible functional consequences in different biological contexts. äNon-CG Methylation in the Human Genome (epmc).pdf DeepDyve Pubget Overpricing