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2015 ; 109
(5
): 452-65
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gab.com Text
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English Wikipedia
Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation
of Circulating and Tissue Citrulline to Small Intestine Epithelial
Histopathology
#MMPMID26425905
Jones JW
; Tudor G
; Li F
; Tong Y
; Katz B
; Farese AM
; MacVittie TJ
; Booth C
; Kane MA
Health Phys
2015[Nov]; 109
(5
): 452-65
PMID26425905
show ga
The use of plasma citrulline as a biomarker for gastrointestinal acute radiation
syndrome via exposure to total-body irradiation in a murine model was
investigated. The radiation exposure covered lethal, mid-lethal, and sub-lethal
gastrointestinal acute radiation syndrome. Plasma citrulline profiles were
generated over the first 6 d following total-body irradiation exposure of 6-15
Gy. In addition, plasma citrulline was comprehensively evaluated in the context
of matching small intestine citrulline and histopathology. Higher plasma
citrulline was significantly associated with lower irradiation doses over the
first 6 d following the irradiation insult. Furthermore, higher plasma citrulline
was significantly associated with higher crypt survival. The correlation of the
plasma citrulline to crypt survival was more robust for higher irradiation doses
and for later time points. The data suggested plasma citrulline was most
informative for reflecting gastrointestinal injury resulting from exposure to
9-15 Gy total-body irradiation covering time-points 2-5 d post the irradiation
insult.