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2016 ; 7
(ä): 4
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English Wikipedia
The time course changes in expression of aquaporin 4 and aquaporin 1 following
global cerebral ischemic edema in rat
#MMPMID26862443
Akdemir G
; Kaymaz F
; Gursoy-Özdemir Y
; Akalan N
; Akdemir ES
Surg Neurol Int
2016[]; 7
(ä): 4
PMID26862443
show ga
BACKGROUND: The aim of this global cerebral ischemia study was to study the
changes in expression levels of aquaporin 4 (AQP4) and AQP1 over time. METHODS:
Sprague-Dawley type male rats were divided into six groups. Sham group and
ischemia/reperfusion were performed on five other groups using the four-vessel
occlusion model. Reperfusion was done 30 min after the occlusion, and each group
was tested at 1, 6, 12, 24, and 48 h for brain wet-dry weight ratio and AQP4 and
AQP1 expression levels using immunohistochemistry. To prove ischemia development
exists in both hippocampal neurons and epithelia of choroid plexus, hematoxylin,
and eosin and? neuronal marker (NeuN) immune-staining have been applied to the
sham experimental group at 48 h. AQP4 expression levels are also measured with
western blotting. RESULTS: After ischemia/reperfusion it is observed that the
decrease in brain water content between 12 and 24 h was statistically significant
(P < 0.01). In parallel and based on immunohistochemical staining, AQP4
expression levels did not exhibit any statistically significant change. AQP4
levels did not show any statistically significant change in western blotting.
AQP1 expression in choroid plexus epithelial cells decreased at the 12 and 24 h
but increased in 48 h (P < 0.05). CONCLUSIONS: Lack of change in AQP4 expression
levels is thought as its dual role in formation and elimination of ischemic brain
edema. Decrease in AQP1 expression levels in 24 h can be explained with necrosis
in choroid plexus after ischemia and the increase in 48 h mark can be related to
recovery in choroid plexus.
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