Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nchembio.1986 http://scihub22266oqcxt.onion/10.1038/nchembio.1986 C4718762!4718762!26656090     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2016 ; 12 (2): 109-16 Nephropedia Template TP {{tp|p=26656090|t=2016. Correlating chemical sensitivity and basal gene expression reveals mechanism of action |pdf=|usr=}}{{26656090}} gab.com Text Correlating chemical sensitivity and basal gene expression reveals mechanism of action JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26656090 #FOAvip Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are unknown. To test this idea, we correlated the sensitivity patterns of 481 compounds with ~19,000 basal transcript levels across 823 different human cancer cell lines and identified selective outlier transcripts. This process yielded many novel mechanistic insights, including the identification of activation mechanisms, cellular transporters, and direct protein targets. We found that ML239, originally identified in a phenotypic screen for selective cytotoxicity in breast cancer stem-like cells, most likely acts through activation of fatty acid desaturase 2 (FADS2). These data and analytical tools are available to the research community through the Cancer Therapeutics Response Portal. Twit Text FOAVip Correlating chemical sensitivity and basal gene expression reveals mechanism of action ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26656090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26656090 #FOAvip English Wikipedia <ref>{{Cite pmid|26656090}}</ref> Correlating chemical sensitivity and basal gene expression reveals mechanism of action #MMPMID26656090 Rees MG; Seashore-Ludlow B; Cheah JH; Adams DJ; Price EV; Gill S; Javaid S; Coletti ME; Jones VL; Bodycombe NE; Soule CK; Alexander B; Li A; Montgomery P; Kotz JD; Hon CSY; Munoz B; Liefeld T; Dan?ík V; Haber DA; Clish CB; Bittker JA; Palmer M; Wagner BK; Clemons PA; Shamji AF; Schreiber SL Nat Chem Biol 2016[Feb]; 12 (2): 109-16 PMID26656090show ga Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are unknown. To test this idea, we correlated the sensitivity patterns of 481 compounds with ~19,000 basal transcript levels across 823 different human cancer cell lines and identified selective outlier transcripts. This process yielded many novel mechanistic insights, including the identification of activation mechanisms, cellular transporters, and direct protein targets. We found that ML239, originally identified in a phenotypic screen for selective cytotoxicity in breast cancer stem-like cells, most likely acts through activation of fatty acid desaturase 2 (FADS2). These data and analytical tools are available to the research community through the Cancer Therapeutics Response Portal. äCorrelating chemical sensitivity and basal gene expression reveals mec(epmc).pdf DeepDyve Pubget Overpricing