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10.1016/j.tem.2015.01.002

http://scihub22266oqcxt.onion/10.1016/j.tem.2015.01.002
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C4718075!4718075!25656826
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suck abstract from ncbi

pmid25656826      Trends+Endocrinol+Metab 2015 ; 26 (3): 153-61
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  • Adipocytokines and Hepatic Fibrosis #MMPMID25656826
  • Saxena NK; Anania FA
  • Trends Endocrinol Metab 2015[Mar]; 26 (3): 153-61 PMID25656826show ga
  • Obesity and metabolic syndrome pose significant risk for progression of many types of chronic illnesses, including liver disease. Hormones released from adipocytes, adipocytokines, associated with obesity and metabolic syndrome, have been shown to control hepatic inflammation and fibrosis. Hepatic fibrosis is the final common pathway that can result in cirrhosis, and can ultimately require liver transplantation. Initially, two key adipocytokines, leptin and adiponectin, appeared to control many fundamental aspects of the cell and molecular biology related to hepatic fibrosis and its resolution. Leptin appears to act as a profibrogenic molecule while adiponectin possesses strong-anti-fibrotic properties. In this review, we emphasize pertinent data associated with these, and recently discovered, adipocytokines that may drive or halt the fibrogenic response in the liver.
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