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High Killips Class as a Predictor of New-onset Atrial Fibrillation Following
Acute Myocardial Infarction: Systematic Review and Meta-analysis
#MMPMID26168839
Zhang EY
; Cui L
; Li ZY
; Liu T
; Li GP
Chin Med J (Engl)
2015[Jul]; 128
(14
): 1964-8
PMID26168839
show ga
BACKGROUND: Recent observational studies have shown that patients with higher
Killips score (>I) have higher risk of new-onset atrial fibrillation (NOAF)
following acute myocardial infarction (AMI), while others drew a neutral
conclusion. The ultimate predictive value of high Killips class on NOAF remained
obscure. METHODS: PubMed, Web of Science, China National Knowledge
Infrastructure, and the Cochrane Controlled Trials Register Databases were
searched until February 2015. Of the 3732 initially identified studies, 5
observational studies with 10,053 patients were analyzed. RESULTS: The
meta-analysis of these studies showed that higher Killips score on admission was
associated with higher incidence of NOAF following AMI (odds ratio = 2.29, 95%
confidence interval 1.96-2.67, P < 0.00001), while no significant differences
exist among individual trials (P = 0.14 and I2 = 43%). CONCLUSIONS: Killips class
>I was associated with the higher opportunity of developing NOAF following AMI.
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