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2015 ; 128
(14
): 1969-76
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gab.com Text
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English Wikipedia
New Delhi Metallo-?-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis,
Treatment and Public Health Concern
#MMPMID26168840
Wei WJ
; Yang HF
; Ye Y
; Li JB
Chin Med J (Engl)
2015[Jul]; 128
(14
): 1969-76
PMID26168840
show ga
OBJECTIVE: To review the origin, diagnosis, treatment and public health concern
of New Delhi metallo-?-lactamase (NDM)-producing bacteria. DATA SOURCES: We
searched database for studies published in English. The database of PubMed from
2007 to 2015 was used to conduct a search using the keyword term "NDM and
Acinetobacter or Enterobacteriaceae or Pseudomonas aeruginosa." STUDY SELECTION:
We collected data including the relevant articles on international transmission,
testing methods and treatment strategies of NDM-positive bacteria. Worldwide NDM
cases were reviewed based on 22 case reports. RESULTS: The first documented case
of infection caused by bacteria producing NDM-1 occurred in India, in 2008. Since
then, 13 blaNDM variants have been reported. The rise of NDM is not only due to
its high rate of genetic transfer among unrelated bacterial species, but also to
human factors such as travel, sanitation and food production and preparation.
With limited treatment options, scientists try to improve available therapies and
create new ones. CONCLUSIONS: In order to slow down the spread of these
NDM-positive bacteria, a series of measures must be implemented. The creation and
transmission of blaNDM are potentially global health issues, which are not issues
for one country or one medical community, but for global priorities in general
and for individual wound care practitioners specifically.