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10.1016/j.tcm.2015.07.002

http://scihub22266oqcxt.onion/10.1016/j.tcm.2015.07.002
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C4715991!4715991!26391345
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suck abstract from ncbi


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pmid26391345      Trends+Cardiovasc+Med 2016 ; 26 (3): 209-18
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  • Mechanisms Contributing to Myocardial Potassium Channel Diversity, Regulation and Remodeling #MMPMID26391345
  • Yang KC; Nerbonne JM
  • Trends Cardiovasc Med 2016[Apr]; 26 (3): 209-18 PMID26391345show ga
  • In the mammalian heart, multiple types of K+ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K+ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K+ channel diversity. Maladaptive remodeling of K+ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational and epigenetic mechanisms contributing to regulating the expression, distribution and remodeling of cardiac K+ channels under physiological and pathological conditions.
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