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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Cardiovasc+Med 2016 ; 26 (3): 209-18 Nephropedia Template TP
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Mechanisms Contributing to Myocardial Potassium Channel Diversity, Regulation and Remodeling #MMPMID26391345
Yang KC; Nerbonne JM
Trends Cardiovasc Med 2016[Apr]; 26 (3): 209-18 PMID26391345show ga
In the mammalian heart, multiple types of K+ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K+ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K+ channel diversity. Maladaptive remodeling of K+ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational and epigenetic mechanisms contributing to regulating the expression, distribution and remodeling of cardiac K+ channels under physiological and pathological conditions.