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10.1242/jcs.175687 http://scihub22266oqcxt.onion/10.1242/jcs.175687 C4712787!4712787!26574505     free     free     free       J+Cell+Sci 2015 ; 128 (22): 4039-45 Nephropedia Template TP {{tp|p=26574505|t=2015. Photoreceptors at a glance |pdf=|usr=}}{{26574505}} gab.com Text Photoreceptors at a glance JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26574505 #FOAvip Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that functions in the capture of light and its conversion into electrical signals in a process known as phototransduction. In rods, photoisomerization of 11-cis to all-trans retinal within rhodopsin triggers a biochemical cascade culminating in the closure of cGMP-gated channels and hyperpolarization of the cell. Biochemical reactions return the cell to its ?dark state? and the visual cycle converts all-trans retinal back to 11-cis retinal for rhodopsin regeneration. OS are continuously renewed, with aged membrane removed at the distal end by phagocytosis and new membrane added at the proximal end through OS disk morphogenesis linked to protein trafficking. The molecular basis for disk morphogenesis remains to be defined in detail although several models have been proposed, and molecular mechanisms underlying protein trafficking are under active investigation. The aim of this Cell Science at a Glance article and the accompanying poster is to highlight our current understanding of photoreceptor structure, phototransduction, the visual cycle, OS renewal, protein trafficking and retinal degenerative diseases. Twit Text FOAVip Photoreceptors at a glance ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26574505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26574505 #FOAvip English Wikipedia <ref>{{Cite pmid|26574505}}</ref> Photoreceptors at a glance #MMPMID26574505 Molday RS; Moritz OL J Cell Sci 2015[Nov]; 128 (22): 4039-45 PMID26574505show ga Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that functions in the capture of light and its conversion into electrical signals in a process known as phototransduction. In rods, photoisomerization of 11-cis to all-trans retinal within rhodopsin triggers a biochemical cascade culminating in the closure of cGMP-gated channels and hyperpolarization of the cell. Biochemical reactions return the cell to its ?dark state? and the visual cycle converts all-trans retinal back to 11-cis retinal for rhodopsin regeneration. OS are continuously renewed, with aged membrane removed at the distal end by phagocytosis and new membrane added at the proximal end through OS disk morphogenesis linked to protein trafficking. The molecular basis for disk morphogenesis remains to be defined in detail although several models have been proposed, and molecular mechanisms underlying protein trafficking are under active investigation. The aim of this Cell Science at a Glance article and the accompanying poster is to highlight our current understanding of photoreceptor structure, phototransduction, the visual cycle, OS renewal, protein trafficking and retinal degenerative diseases. äPhotoreceptors at a glance (epmc).pdf DeepDyve Pubget Overpricing