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10.1016/j.ccm.2014.11.002

http://scihub22266oqcxt.onion/10.1016/j.ccm.2014.11.002
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C4710582!4710582!25676522
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suck abstract from ncbi


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pmid25676522      Clin+Chest+Med 2015 ; 36 (1): 91-9
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  • Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts #MMPMID25676522
  • Henkle E; Winthrop K
  • Clin Chest Med 2015[Mar]; 36 (1): 91-9 PMID25676522show ga
  • Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Historically acquired immunodeficiency virus (AIDS), cancer, and hematologic and solid organ transplants have been associated with NTM disease. More recently, immunosuppressive drugs including anti-tumor necrosis factor (anti-TNF) biologics have been associated with NTM disease in population-based studies. Extrapulmonary NTM disease, including disseminated and skin and catheter-related disease, is more common in immunosuppressed compared to immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection of all sites, but rapid growers including M. abscessus, M. chelonae, and M. fortuitum play an important role in skin and catheter-related infections. With the exception of prophylaxis for AIDS patients with very low CD4+ counts, the prevention of NTM remains difficult. Management is complicated and involves restoring immune function and removing catheters in addition to treatment with species-specific antibiotic treatment per current ATS/IDSA guidelines.
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