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10.1007/s00432-014-1767-3 http://scihub22266oqcxt.onion/10.1007/s00432-014-1767-3 C4710367!4710367!25005786     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cancer+Res+Clin+Oncol 2015 ; 141 (5): 769-84 Nephropedia Template TP {{tp|p=25005786|t=2015. Cancer active targeting by nanoparticles: a comprehensive review of literature |pdf=|usr=}}{{25005786}} gab.com Text Cancer active targeting by nanoparticles: a comprehensive review of literature JO: J Cancer Res Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25005786 #FOAvip Purpose: Cancer is one of the leading causes of death, and thus, the scientific community has but great efforts to improve cancer management. Among the major challenges in cancer management is development of agents that can be used for early diagnosis and effective therapy. Conventional cancer management frequently lacks accurate tools for detection of early tumors and has an associated risk of serious side effects of chemotherapeutics. The need to optimize therapeutic ratio as the difference with which a treatment affects cancer cells versus healthy tissues lead to idea that it is needful to have a treatment that could act a the ?magic bullet??recognize cancer cells only. Nanoparticle platforms offer a variety of potentially efficient solutions for development of targeted agents that can be exploited for cancer diagnosis and treatment. There are two ways by which targeting of nanoparticles can be achieved, namely passive and active targeting. Passive targeting allows for the efficient localization of nanoparticles within the tumor microenvironment. Active targeting facilitates the active uptake of nanoparticles by the tumor cells themselves. Methods: Relevant English electronic databases and scientifically published original articles and reviews were systematically searched for the purpose of this review. Results: In this report, we present a comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-based targeting, aptamer-based targeting, as well as ligand-based targeting. Conclusion: To date, the optimum targeting strategy has not yet been announced, each has its own advantages and disadvantages even though a number of them have found their way for clinical application. Perhaps, a combination of strategies can be employed to improve the precision of drug delivery, paving the way for a more effective personalized therapy. Twit Text FOAVip Cancer active targeting by nanoparticles: a comprehensive review of literature ????J Cancer Res Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25005786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25005786 #FOAvip English Wikipedia <ref>{{Cite pmid|25005786}}</ref> Cancer active targeting by nanoparticles: a comprehensive review of literature #MMPMID25005786 Bazak R; Houri M; Achy SE; Kamel S; Refaat T J Cancer Res Clin Oncol 2015[May]; 141 (5): 769-84 PMID25005786show ga Purpose: Cancer is one of the leading causes of death, and thus, the scientific community has but great efforts to improve cancer management. Among the major challenges in cancer management is development of agents that can be used for early diagnosis and effective therapy. Conventional cancer management frequently lacks accurate tools for detection of early tumors and has an associated risk of serious side effects of chemotherapeutics. The need to optimize therapeutic ratio as the difference with which a treatment affects cancer cells versus healthy tissues lead to idea that it is needful to have a treatment that could act a the ?magic bullet??recognize cancer cells only. Nanoparticle platforms offer a variety of potentially efficient solutions for development of targeted agents that can be exploited for cancer diagnosis and treatment. There are two ways by which targeting of nanoparticles can be achieved, namely passive and active targeting. Passive targeting allows for the efficient localization of nanoparticles within the tumor microenvironment. Active targeting facilitates the active uptake of nanoparticles by the tumor cells themselves. Methods: Relevant English electronic databases and scientifically published original articles and reviews were systematically searched for the purpose of this review. Results: In this report, we present a comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-based targeting, aptamer-based targeting, as well as ligand-based targeting. Conclusion: To date, the optimum targeting strategy has not yet been announced, each has its own advantages and disadvantages even though a number of them have found their way for clinical application. Perhaps, a combination of strategies can be employed to improve the precision of drug delivery, paving the way for a more effective personalized therapy. äCancer active targeting by nanoparticles: a comprehensive review of li(epmc).pdf DeepDyve Pubget Overpricing