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10.1002/med.21327 http://scihub22266oqcxt.onion/10.1002/med.21327 C4710177!4710177 !25164622     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25164622 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Res+Rev 2015 ; 35 (2 ): 225-85 Nephropedia Template TP {{tp|p=25164622 |t=2015. Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications |pdf=|usr=}}{{25164622 }} gab.com Text Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications JO: Med Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=25164622 #FOAvip Ribosomes are essential components of the protein synthesis machinery. The process of ribosome biogenesis is well organized and tightly regulated. Recent studies have shown that ribosomal proteins (RPs) have extraribosomal functions that are involved in cell proliferation, differentiation, apoptosis, DNA repair, and other cellular processes. The dysfunction of RPs has been linked to the development and progression of hematological, metabolic, and cardiovascular diseases and cancer. Perturbation of ribosome biogenesis results in ribosomal stress, which triggers activation of the p53 signaling pathway through RPs-MDM2 interactions, resulting in p53-dependent cell cycle arrest and apoptosis. RPs also regulate cellular functions through p53-independent mechanisms. We herein review the recent advances in several forefronts of RP research, including the understanding of their biological features and roles in regulating cellular functions, maintaining cell homeostasis, and their involvement in the pathogenesis of human diseases. We also highlight the translational potential of this research for the identification of molecular biomarkers, and in the discovery and development of novel treatments for human diseases. Twit Text FOAVip Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications ????Med Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=25164622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25164622 #FOAvip English Wikipedia <ref>{{Cite pmid|25164622 }}</ref> Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications #MMPMID25164622 Wang W ; Nag S ; Zhang X ; Wang MH ; Wang H ; Zhou J ; Zhang R Med Res Rev 2015[Mar]; 35 (2 ): 225-85 PMID25164622 show ga Ribosomes are essential components of the protein synthesis machinery. The process of ribosome biogenesis is well organized and tightly regulated. Recent studies have shown that ribosomal proteins (RPs) have extraribosomal functions that are involved in cell proliferation, differentiation, apoptosis, DNA repair, and other cellular processes. The dysfunction of RPs has been linked to the development and progression of hematological, metabolic, and cardiovascular diseases and cancer. Perturbation of ribosome biogenesis results in ribosomal stress, which triggers activation of the p53 signaling pathway through RPs-MDM2 interactions, resulting in p53-dependent cell cycle arrest and apoptosis. RPs also regulate cellular functions through p53-independent mechanisms. We herein review the recent advances in several forefronts of RP research, including the understanding of their biological features and roles in regulating cellular functions, maintaining cell homeostasis, and their involvement in the pathogenesis of human diseases. We also highlight the translational potential of this research for the identification of molecular biomarkers, and in the discovery and development of novel treatments for human diseases. |*Disease [MESH] |Cell Nucleolus/metabolism [MESH] |Humans [MESH] |Mitochondria/metabolism [MESH] |Ribosomal Proteins/*metabolism [MESH] |Ribosomes/metabolism [MESH]Ribosomal proteins and human diseases: pathogenesis, molecular mechani(epmc).pdf DeepDyve Pubget Overpricing