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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Med
2016 ; 22
(1
): 72-7
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Early-life compartmentalization of human T cell differentiation and regulatory
function in mucosal and lymphoid tissues
#MMPMID26657141
Thome JJ
; Bickham KL
; Ohmura Y
; Kubota M
; Matsuoka N
; Gordon C
; Granot T
; Griesemer A
; Lerner H
; Kato T
; Farber DL
Nat Med
2016[Jan]; 22
(1
): 72-7
PMID26657141
show ga
It is unclear how the immune response in early life becomes appropriately
stimulated to provide protection while also avoiding excessive activation as a
result of diverse new antigens. T cells are integral to adaptive immunity; mouse
studies indicate that tissue localization of T cell subsets is important for both
protective immunity and immunoregulation. In humans, however, the early
development and function of T cells in tissues remain unexplored. We present here
an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ
donors in the first two years of life, as compared to adult organ donors,
revealing early compartmentalization of T cell differentiation and regulation.
Whereas adult tissues contain a predominance of memory T cells, in pediatric
blood and tissues the main subset consists of naive recent thymic emigrants, with
effector memory T cells (T(EM)) found only in the lungs and small intestine.
Additionally, regulatory T (T(reg)) cells comprise a high proportion (30-40%) of
CD4(+) T cells in pediatric tissues but are present at much lower frequencies
(1-10%) in adult tissues. Pediatric tissue T(reg) cells suppress endogenous T
cell activation, and early T cell functionality is confined to the mucosal sites
that have the lowest T(reg):T(EM) cell ratios, which suggests control in situ of
immune responses in early life.
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