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10.1016/j.gene.2015.07.011 http://scihub22266oqcxt.onion/10.1016/j.gene.2015.07.011 C4702260!4702260!26172868     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2015 ; 572 (2): 191-7 Nephropedia Template TP {{tp|p=26172868|t=2015. MSPrecise: a molecular diagnostic test for multiple sclerosis using next generation sequencing |pdf=|usr=}}{{26172868}} gab.com Text MSPrecise: a molecular diagnostic test for multiple sclerosis using next generation sequencing JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=26172868 #FOAvip Background: We have previously demonstrated that cerebrospinal fluid-derived B cells from early relapsing-remitting multiple sclerosis (RRMS) patients that express a VH4 gene accumulate specific replacement mutations that can be quantified as a score that identifies such patients as having or likely to convert to RRMS. Furthermore, we showed that next generation sequencing is an efficient method for obtaining the sequencing information required by this mutation scoring tool, originally developed using the less clinically viable single-cell Sanger sequencing. Objective: To determine the accuracy of MSPrecise, the diagnostic test that identifies the presence of the RRMS-enriched mutation pattern from patient cerebrospinal fluid B cells. Methods: Cerebrospinal fluid cell pellets were obtained from RRMS and other neurological disease (OND) patient cohorts. VH4 gene segments were amplified, sequenced by next generation sequencing and analyzed for mutation score. Results: The diagnostic test showed a sensitivity of 75% on the RRMS cohort and a specificity of 88% on the OND cohort. The accuracy of the test in identifying RRMS patients or patients that will develop RRMS is 84%. Conclusion: MSPrecise exhibits good performance in identifying patients with RRMS irrespective of time with RRMS. Twit Text FOAVip MSPrecise: a molecular diagnostic test for multiple sclerosis using next generation sequencing ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=26172868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26172868 #FOAvip English Wikipedia <ref>{{Cite pmid|26172868}}</ref> MSPrecise: a molecular diagnostic test for multiple sclerosis using next generation sequencing #MMPMID26172868 Rounds WH; Salinas EA; Wilks TB; Levin MK; Ligocki AJ; Ionete C; Pardo-Villamizar C; Vernino S; Greenberg BM; Bigwood DW; Eastman EM; Cowell LG; Monson NL Gene 2015[Nov]; 572 (2): 191-7 PMID26172868show ga Background: We have previously demonstrated that cerebrospinal fluid-derived B cells from early relapsing-remitting multiple sclerosis (RRMS) patients that express a VH4 gene accumulate specific replacement mutations that can be quantified as a score that identifies such patients as having or likely to convert to RRMS. Furthermore, we showed that next generation sequencing is an efficient method for obtaining the sequencing information required by this mutation scoring tool, originally developed using the less clinically viable single-cell Sanger sequencing. Objective: To determine the accuracy of MSPrecise, the diagnostic test that identifies the presence of the RRMS-enriched mutation pattern from patient cerebrospinal fluid B cells. Methods: Cerebrospinal fluid cell pellets were obtained from RRMS and other neurological disease (OND) patient cohorts. VH4 gene segments were amplified, sequenced by next generation sequencing and analyzed for mutation score. Results: The diagnostic test showed a sensitivity of 75% on the RRMS cohort and a specificity of 88% on the OND cohort. The accuracy of the test in identifying RRMS patients or patients that will develop RRMS is 84%. Conclusion: MSPrecise exhibits good performance in identifying patients with RRMS irrespective of time with RRMS. äMSPrecise: a molecular diagnostic test for multiple sclerosis using ne(epmc).pdf DeepDyve Pubget Overpricing