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10.1016/j.chom.2015.10.009 http://scihub22266oqcxt.onion/10.1016/j.chom.2015.10.009 C4701053!4701053!26567512     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2015 ; 18 (5): 613-20 Nephropedia Template TP {{tp|p=26567512|t=2015. Individual members of the microbiota disproportionately modulate host innate immune responses |pdf=|usr=}}{{26567512}} gab.com Text Individual members of the microbiota disproportionately modulate host innate immune responses JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26567512 #FOAvip Predicting host health status based on microbial community structure is a major goal of microbiome research. An implicit assumption of microbiome profiling for diagnostic purposes is that the proportional representation of different taxa determine host phenotypes. To test this assumption, we colonized gnotobiotic zebrafish with zebrafish-derived bacterial isolates and measured bacterial abundance and host neutrophil responses. Surprisingly, combinations of bacteria elicited immune responses that do not reflect the numerically dominant species. These data are consistent with a quantitative model in which the host responses to commensal species are additive, but where various species have different per capita immunostimulatory effects. For example, one species has a high per capita immunosuppression that is mediated through a potent secreted factor. We conclude that the proportional representation of bacteria in a community does not necessarily predict its functional capacities; however, characterizing specific properties of individual species offers predictive insights into multi-species community function. Twit Text FOAVip Individual members of the microbiota disproportionately modulate host innate immune responses ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26567512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26567512 #FOAvip English Wikipedia <ref>{{Cite pmid|26567512}}</ref> Individual members of the microbiota disproportionately modulate host innate immune responses #MMPMID26567512 Rolig AS; Parthasarathy R; Burns AR; Bohannan BJ; Guillemin K Cell Host Microbe 2015[Nov]; 18 (5): 613-20 PMID26567512show ga Predicting host health status based on microbial community structure is a major goal of microbiome research. An implicit assumption of microbiome profiling for diagnostic purposes is that the proportional representation of different taxa determine host phenotypes. To test this assumption, we colonized gnotobiotic zebrafish with zebrafish-derived bacterial isolates and measured bacterial abundance and host neutrophil responses. Surprisingly, combinations of bacteria elicited immune responses that do not reflect the numerically dominant species. These data are consistent with a quantitative model in which the host responses to commensal species are additive, but where various species have different per capita immunostimulatory effects. For example, one species has a high per capita immunosuppression that is mediated through a potent secreted factor. We conclude that the proportional representation of bacteria in a community does not necessarily predict its functional capacities; however, characterizing specific properties of individual species offers predictive insights into multi-species community function. äIndividual members of the microbiota disproportionately modulate host (epmc).pdf DeepDyve Pubget Overpricing