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10.1016/j.cell.2015.08.052 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.08.052 C4700833!4700833!26359984     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 162 (6): 1242-56 Nephropedia Template TP {{tp|p=26359984|t=2015. Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth |pdf=|usr=}}{{26359984}} gab.com Text Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26359984 #FOAvip Therapeutic antibodies targeting programmed cell death-1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of melanoma. Yet, little is known about tumor cell-intrinsic PD-1 pathway effects. Here we show that murine and human melanomas contain PD-1-expressing cancer subpopulations and demonstrate that melanoma cell-intrinsic PD-1 promotes tumorigenesis, even in mice lacking adaptive immunity. PD-1 inhibition on melanoma cells by RNA interference, blocking antibodies, or mutagenesis of melanoma-PD-1 signaling motifs suppresses tumor growth in immunocompetent, immunocompromised and PD-1-deficient tumor graft recipient mice. Conversely, melanoma-specific PD-1 overexpression enhances tumorigenicity, as does engagement of melanoma-PD-1 by its ligand, PD-L1, whereas melanoma-PD-L1 inhibition or knockout of host-PD-L1 attenuate growth of PD-1-positive melanomas. Mechanistically, the melanoma-PD-1 receptor modulates downstream effectors of mTOR signaling. Our results identify melanoma cell-intrinsic functions of the PD-1:PD-L1 axis in tumor growth and suggest that blocking melanoma-PD-1 might contribute to the striking clinical efficacy of anti-PD-1 therapy. Twit Text FOAVip Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26359984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26359984 #FOAvip English Wikipedia <ref>{{Cite pmid|26359984}}</ref> Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth #MMPMID26359984 Kleffel S; Posch C; Barthel SR; Mueller H; Schlapbach C; Guenova E; Elco CP; Lee N; Juneja VR; Zhan Q; Lian CG; Thomi R; Hoetzenecker W; Cozzio A; Dummer R; Mihm MC; Flaherty KT; Frank MH; Murphy GF; Sharpe AH; Kupper TS; Schatton T Cell 2015[Sep]; 162 (6): 1242-56 PMID26359984show ga Therapeutic antibodies targeting programmed cell death-1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of melanoma. Yet, little is known about tumor cell-intrinsic PD-1 pathway effects. Here we show that murine and human melanomas contain PD-1-expressing cancer subpopulations and demonstrate that melanoma cell-intrinsic PD-1 promotes tumorigenesis, even in mice lacking adaptive immunity. PD-1 inhibition on melanoma cells by RNA interference, blocking antibodies, or mutagenesis of melanoma-PD-1 signaling motifs suppresses tumor growth in immunocompetent, immunocompromised and PD-1-deficient tumor graft recipient mice. Conversely, melanoma-specific PD-1 overexpression enhances tumorigenicity, as does engagement of melanoma-PD-1 by its ligand, PD-L1, whereas melanoma-PD-L1 inhibition or knockout of host-PD-L1 attenuate growth of PD-1-positive melanomas. Mechanistically, the melanoma-PD-1 receptor modulates downstream effectors of mTOR signaling. Our results identify melanoma cell-intrinsic functions of the PD-1:PD-L1 axis in tumor growth and suggest that blocking melanoma-PD-1 might contribute to the striking clinical efficacy of anti-PD-1 therapy. äMelanoma cell-intrinsic PD-1 receptor functions promote tumor growth (epmc).pdf DeepDyve Pubget Overpricing