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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Neurodegener+Dis
2015 ; 4
(2
): 49
Nephropedia Template TP
gab.com Text
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English Wikipedia
Erratum: Development, appraisal, validation and implementation of a consensus
protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain
tissue
#MMPMID26807344
Love S
; Chalmers K
; Ince P
; Esiri M
; Attems J
; Kalaria R
; Jellinger K
; Yamada M
; McCarron M
; Minett T
; Matthews F
; Greenberg S
; Mann D
; Kehoe PG
Am J Neurodegener Dis
2015[]; 4
(2
): 49
PMID26807344
show ga
In a collaboration involving 11 groups with research interests in cerebral
amyloid angiopathy (CAA), we used a two-stage process to develop and in turn
validate a new consensus protocol and scoring scheme for the assessment of CAA
and associated vasculopathic abnormalities in post-mortem brain tissue. Stage one
used an iterative Delphi-style survey to develop the consensus protocol. The
resultant scoring scheme was tested on a series of digital images and paraffin
sections that were circulated blind to a number of scorers. The scoring scheme
and choice of staining methods were refined by open-forum discussion. The agreed
protocol scored parenchymal and meningeal CAA on a 0-3 scale, capillary CAA as
present/absent and vasculopathy on 0-2 scale, in the 4 cortical lobes that were
scored separately. A further assessment involving three centres was then
undertaken. Neuropathologists in three centres (Bristol, Oxford and Sheffield)
independently scored sections from 75 cases (25 from each centre) and high
inter-rater reliability was demonstrated. Stage two used the results of the
three-centre assessment to validate the protocol by investigating previously
described associations between APOE genotype (previously determined), and both
CAA and vasculopathy. Association of capillary CAA with or without arteriolar CAA
with APOE ?4 was confirmed. However APOE ?2 was also found to be a strong risk
factor for the development of CAA, not only in AD but also in elderly
non-demented controls. Further validation of this protocol and scoring scheme is
encouraged, to aid its wider adoption to facilitate collaborative and replication
studies of CAA.[This corrects the article on p. 19 in vol. 3, PMID: 24754000.].