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10.1016/j.exer.2015.07.013 http://scihub22266oqcxt.onion/10.1016/j.exer.2015.07.013 C4698029!4698029!26226231     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Eye+Res 2016 ; 144 (ä): 29-37 Nephropedia Template TP {{tp|p=26226231|t=2016. The Autophagic Lysosomal System in Outflow Pathway Physiology and Pathophysiology |pdf=|usr=}}{{26226231}} gab.com Text The Autophagic Lysosomal System in Outflow Pathway Physiology and Pathophysiology JO: Exp Eye Res http://www.kidney.de/pget.php?&tw=1&pmid=26226231 #FOAvip Malfunction of the trabecular meshwork (TM)/schlemm?s canal (SC) conventional outflow pathway is associated with elevated intraocular pressure (IOP) and, therefore, increased risk of developing glaucoma, a potentially blinding disease affecting more than 70 million people worldwide. This TM/SC tissue is subjected to different types of stress, including mechanical, oxidative, and phagocytic stress. Long-term exposure to these stresses is believed to lead to a progressive accumulation of damaged cellular and tissue structures causing permanent alterations in the tissue physiology, and contribute to the pathologic increase in aqueous humor (AH) outflow resistance. Autophagy is emerging as an essential cellular survival mechanism against a variety of stressors. In addition to performing basal functions, autophagy acts as a cellular survival pathway and represents an essential mechanism by which organisms can adapt to acute stress conditions and repair stress-induced damage. A decline in autophagy has been observed in most tissues with aging and has been considered responsible, at least in part, for the accumulation of damaged cellular components in almost all tissues of aging organisms. Dysfunction in the autophagy pathway is associated with several human diseases, from infectious diseases to cancer and neurodegeneration. In this review, we will summarize our current knowledge of the emerging roles of autophagy in outflow tissue physiology and pathophysiology, including novel evidence suggesting compromised autophagy in the glaucomatous outflow pathway. Twit Text FOAVip The Autophagic Lysosomal System in Outflow Pathway Physiology and Pathophysiology ????Exp Eye Res http://www.kidney.de/pget.php?&tw=1&pmid=26226231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26226231 #FOAvip English Wikipedia <ref>{{Cite pmid|26226231}}</ref> The Autophagic Lysosomal System in Outflow Pathway Physiology and Pathophysiology #MMPMID26226231 Liton PB Exp Eye Res 2016[Mar]; 144 (ä): 29-37 PMID26226231show ga Malfunction of the trabecular meshwork (TM)/schlemm?s canal (SC) conventional outflow pathway is associated with elevated intraocular pressure (IOP) and, therefore, increased risk of developing glaucoma, a potentially blinding disease affecting more than 70 million people worldwide. This TM/SC tissue is subjected to different types of stress, including mechanical, oxidative, and phagocytic stress. Long-term exposure to these stresses is believed to lead to a progressive accumulation of damaged cellular and tissue structures causing permanent alterations in the tissue physiology, and contribute to the pathologic increase in aqueous humor (AH) outflow resistance. Autophagy is emerging as an essential cellular survival mechanism against a variety of stressors. In addition to performing basal functions, autophagy acts as a cellular survival pathway and represents an essential mechanism by which organisms can adapt to acute stress conditions and repair stress-induced damage. A decline in autophagy has been observed in most tissues with aging and has been considered responsible, at least in part, for the accumulation of damaged cellular components in almost all tissues of aging organisms. Dysfunction in the autophagy pathway is associated with several human diseases, from infectious diseases to cancer and neurodegeneration. In this review, we will summarize our current knowledge of the emerging roles of autophagy in outflow tissue physiology and pathophysiology, including novel evidence suggesting compromised autophagy in the glaucomatous outflow pathway. äThe Autophagic Lysosomal System in Outflow Pathway Physiology and Path(epmc).pdf DeepDyve Pubget Overpricing